Feb 16, 2021 Tilaciclib is first drug approved for this indication WASHINGTON—The FDA approved tilaciclib (Cosela) to reduce chemotherapy-induced bone marrow suppression in adults. Tilaciclib, which protects bone marrow cells by inhibiting cyclin-dependent kinase 4/6, is the first drug to win FDA approval for this indication. In a prepared statement from the FDA, Albert Deisseroth, MD, PhD, supervisory medical officer in the Division of Non-Malignant Hematology in the FDA’s Center for Drug Evaluation and Research, said, “For patients with extensive-stage small cell lung cancer, protecti...