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Dynamic model of SARS-CoV-2 spike protein reveals potential new vaccine targets

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IMAGE: In this visualization of antibody target sites, the SARS-CoV-2 spike protein is tethered to the viral membrane with a slender stalk. Patches of intense purple color at the surface of.
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Credit: Mateusz Sikora, Sören von Bülow, Florian E. C. Blanc, Michael Gecht, Roberto Covino and Gerhard Hummer
A new, detailed model of the surface of the SARS-CoV-2 spike protein reveals previously unknown vulnerabilities that could inform development of vaccines. Mateusz Sikora of the Max Planck Institute of Biophysics in Frankfurt, Germany, and colleagues present these findings in the open-access journal
PLOS Computational Biology.
SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. A key feature of SARS-CoV-2 is its spike protein, which extends from its surface and enables it to target and infect human cells. Extensive research has resulted in detailed static models of the spike protein, but these models do not capture the ....

Mateusz Sikora , Entwicklung Wissenschaftlich , Human Frontier Science Program , Frankfurt Institute For Advanced , Max Planck Institute Of Biophysics , Leibniz Supercomputing Centre Munich , Austrian Science Fund , Max Planck Society , Max Planck Institute , Frankfurt Institute , Advanced Studies , Cell Biology , Mathematics Statistics , Algorithms Models , Medicine Health , Infectious Emerging Diseases , மனிதன் எல்லை அறிவியல் ப்ரோக்ர்யாம் , ஆஸ்திரேலிய அறிவியல் நிதி , பிராங்க்ஃபர்ட் நிறுவனம் , செல் உயிரியல் , கணிதம் புள்ளிவிவரங்கள் , மருந்து ஆரோக்கியம் , தொற்று வளர்ந்து வருகிறது நோய்கள் ,

Evidence of Antarctic glacier's tipping point confirmed for first time

Credit: Dr Sebastian Rosier
Researchers have confirmed for the first time that Pine Island Glacier in West Antarctica could cross tipping points, leading to a rapid and irreversible retreat which would have significant consequences for global sea level.
Pine Island Glacier is a region of fast-flowing ice draining an area of West Antarctica approximately two thirds the size of the UK. The glacier is a particular cause for concern as it is losing more ice than any other glacier in Antarctica.
Currently, Pine Island Glacier together with its neighbouring Thwaites glacier are responsible for about 10% of the ongoing increase in global sea level. ....

United States , United Kingdom , Hilmar Gudmundsson , Amundsen Sea , Environmental Sciences , International Thwaites Glacier Collaboration , Research Fellow In Northumbria Department Of Geography , Northumbria University , Pine Island Glacier , West Antarctica , Island Glacier , West Antarctic Ice Sheet , Circumpolar Deep Water , Research Fellow , Professor Hilmar Gudmundsson , Antarctic Ice Sheet , Extreme Environments , Climate Science , Earth Science , Geophysics Gravity , Hydrology Water Resources , Algorithms Models , Climate Change , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , ஹில்மார் குட்முந்ட்ஸ்சோன் ,

First-of-its-kind mechanical model simulates bending of mammalian whiskers

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IMAGE: Mechanics is key to whisker tactile sensation. When a whisker is deflected, its deformation profile within the follicle determines the activity of different groups of mechanoreceptors.
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Credit: Yifu Luo and Nadina Zweifel
Researchers have developed a new mechanical model that simulates how whiskers bend within a follicle in response to an external force, paving the way toward better understanding of how whiskers contribute to mammals sense of touch. Yifu Luo and Mitra Hartmann of Northwestern University and colleagues present these findings in the open-access journal
PLOS Computational Biology.
With the exception of some primates, most mammals use whiskers to explore their environment through the sense of touch. Whiskers have no sensors along their length, but when an external force bends a whisker, that deformation extends into the follicle at the base of the whisker, where the whisker pushes or pulls on sensor cells, t ....

Yifu Luo , Mitra Hartmann , Northwestern University , Biomechanics Biophysics , Zoology Veterinary Science , Mathematics Statistics , Algorithms Models , மித்ரா ஹார்ட்மேன் , வடமேற்கு பல்கலைக்கழகம் , பயோமெக்கானிக்ஸ் உயிர் இயற்பியல் , ஸுவாலஜீ கால்நடை அறிவியல் , கணிதம் புள்ளிவிவரங்கள் ,

Keeping it fresh: New AI-based strategy can assess the freshness of beef samples

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IMAGE: Consuming spoiled beef is dangerous, but there are currently no simple and efficient methods to assess beef freshness.
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Credit: Unsplash
Although beef is one of the most consumed foods around the world, eating it when it s past its prime is not only unsavory, but also poses some serious health risks. Unfortunately, available methods to check for beef freshness have various disadvantages that keep them from being useful to the public. For example, chemical analysis or microbial population evaluations take too much time and require the skills of a professional. On the other hand, non-destructive approaches based on near-infrared spectroscopy require expensive and sophisticated equipment. Could artificial intelligence be the key to a more cost-effective way to assess the freshness of beef? ....

South Korea , Kwangju Gwangyoksi , Kyoobin Lee , Jae Gwan Kim , Gwangju Institute Of Science , Gwangju Institute , Associate Processors Kyoobin Lee , Proud Creator , Future Science , Health Care , Algorithms Models , Medicine Health , Health Care Systems Services , Public Health , Technology Engineering Computer Science , Research Development , தெற்கு கொரியா , ஜே குவன் கிம் , குவங்ஜு நிறுவனம் ஆஃப் அறிவியல் , குவங்ஜு நிறுவனம் , ப்ரௌட் உருவாக்கியவர் , எதிர்கால அறிவியல் , ஆரோக்கியம் பராமரிப்பு , மருந்து ஆரோக்கியம் , ஆரோக்கியம் பராமரிப்பு அமைப்புகள் சேவைகள் , பொது ஆரோக்கியம் ,

Consumers are searching online but not buying. Why?

Key Takeaways:
Discounting or couponing is not the most effective way to tap the power of retargeting in online marketing.
Customized seller recommendations may be more powerful than discounting.
Seller auctions that allow marketers to self-select in the retargeting process improve cost efficiency.
CATONSVILLE, MD, April 1, 2021 - Online marketers have seen the pattern: 95%-98% of online visitors search for something, but the search never converts into a purchase and they leave the site without buying. For marketers, this results in speculation and assumptions that can lead to wasted time and investments in ineffective marketing programs.
One of the more common ways online marketers attempt to solve this problem is to retarget, which tracks those consumers and reconnects with them at a later point by showing display ads when they browse other websites. You ve probably noticed this when using Google Search to find something, such as a pair of shoes, and then ....

United States , Thai Che , Zhenling Jiang , Youwei Wang , University Of California , Wharton School , Fudan University , University Of Pennsylvania , Washington University In St , Key Takeaways , Google Search , Marketing Science , Retargeting Based , Consumer Online Behaviors , Tat Chan , Washington University , Algorithms Models , Social Behavioral Science , Information Management Tracking Systems , Management Science Operations Research , Mass Media , ஒன்றுபட்டது மாநிலங்களில் , ஹாய் சே , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , வார்டன் பள்ளி , பல்கலைக்கழகம் ஆஃப் பென்சில்வேனியா ,