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Mink-derived SARS-CoV-2 mutations reduce antibody effectiveness


Mink-derived SARS-CoV-2 mutations reduce antibody effectiveness
The ongoing coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is thought to be a disease originally occurring in animals but transmitted across the species barrier to human beings, probably through an intermediate host. Following human infection, the virus has been shown to transmit to some pet and farm animals, where it then mutates. A new preprint research paper posted to the
bioRxiv server shows that these mutations disrupt inhibition by neutralizing antibodies, both natural and therapeutic.
History of mink SARS-CoV-2 infection
The American mink is a profitable business focus, farmed for its fur in the Netherlands and many other countries. The first case of SARS-CoV-2 infection in farmed mink on a Dutch farm was identified in April 2020. The application of whole-genome sequencing showed that the virus was acquired from humans. ....

United States , Liji Thomas , American Mink , European Mink , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Cell Line , Corona Virus , Coronavirus Disease Covid 19 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஒன்றுபட்டது மாநிலங்களில் , அமெரிக்கன் மிங்க் , ஐரோப்பிய மிங்க் , செல் வரி , கொரோனா வைரஸ் , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

Vaccine candidate containing tetanus toxoid potentially protective against SARS-CoV-2


Vaccine candidate containing tetanus toxoid potentially protective against SARS-CoV-2
Researchers from Cuba, China, and France have demonstrated the potential of coupling a viral antigen with the tetanus toxoid protein as a vaccination approach to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).
Tetanus toxoid (TT) is a chemically inactivated version of the tetanus toxin produced by the bacteria Clostridium tetani. This chemically inactivated antigen can be used as a protein carrier in vaccines to induce potent immune responses in vivo.
The SARS-CoV-2 infection process is mediated by a surface structure called the spike protein. The receptor-binding (RBD) domain of this spike protein contains a receptor-binding motif (RBM) that mediates the interaction of the RBD with the host cell receptor angiotensin-converting enzyme 2 (ACE2). ....

Ciudad De La Habana , Yury Valdes Balbin , Sally Robertson , Finlay Vaccine Institute , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Animal Model , Clinical Trial , Corona Virus , Coronavirus Disease Covid 19 , Immune Response , In Vivo , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , யடட டி லா ஹபனா , சாலி ராபர்ட்சன் , ஃபின்லே தடுப்பூசி நிறுவனம் , விலங்கு மாதிரி , மருத்துவ சோதனை , கொரோனா வைரஸ் , நோய் எதிர்ப்பு சக்தி பதில் , இல் விவோ , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,