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Effect of mutations in the South African SARS-CoV-2 variant on transmission and neutralization

One such strain is the South African 501.V2 and UK B1.1.7 strains, which have been isolated from many countries and seem to spread faster than the ancestral strain. A preprint that recently appeared on the bioRxiv server reports the computational structure of this strain and the possible effect of the mutations on infectivity and neutralization. ....

South Africa , United Kingdom , South African , Liji Thomas , Structure Based Computational , Image Credit , Corona Borealis Studio , Southern African , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Binding Affinity , Corona Virus , Coronavirus Disease Covid 19 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஒன்றுபட்டது கிஂக்டம் , அமைப்பு அடிப்படையிலானது கணக்கீட்டு , படம் கடன் , கொரோனா போரியாலிஸ் ஸ்டுடியோ , பிணைப்பு இன உறவு , கொரோனா வைரஸ் , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

Hypoxia signaling pathway could lead to COVID-19 treatments

Hypoxia signaling pathway could lead to COVID-19 treatments
Researchers in Spain have demonstrated that studying the hypoxia signaling pathway could provide opportunities for treating coronavirus disease 2019 (COVID-19).
The team conducted a study showing that hypoxic (oxygen-deficient) conditions reduced the expression of host cell receptors for the causative agent – severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Hypoxic conditions reduced expression of angiotensin-converting enzyme 2 (ACE2) – the primary host cell receptor required for viral attachment and entry. They also decreased the expression of heparan sulfate (HS), another receptor known to be required for SARS-CoV-2 attachment.
The team – from the Basque Research and Technology Alliance in Derio and the Basque Foundation for Science in Bilbao also showed that hypoxia decreased HS levels through reduced expression of the main HS-containing proteoglycans (HSPGs) – syndecan-1 and synde ....

Pais Vasco , Sally Robertson , Basque Research , Technology Alliance In Derio , Basque Foundation For Science , Technology Alliance , Basque Foundation , Asis Palazon , Signaling Pathway , Angiotensin Converting Enzyme 2 , Cell Line , Corona Virus , Coronavirus Disease Covid 19 , Flow Cytometry , Gene Expression , Sars Cov 2 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , பைஸ் வாஸ்கோ , சாலி ராபர்ட்சன் , பசியூ ஆராய்ச்சி , தொழில்நுட்பம் கூட்டணி இல் டெரியோ , பசியூ அடித்தளம் க்கு அறிவியல் , தொழில்நுட்பம் கூட்டணி , பசியூ அடித்தளம் ,

Researchers map genetic changes that may have facilitated SARS-CoV-2's jump from bats to humans

Researchers from the University of Cambridge and the Pirbright Institute in the UK have identified key genetic changes in SARS-CoV-2 that may be responsible for the virus’s jump from bats to humans. The team also determined which animals contain cellular receptors that allow the virus to enter cells more effectively, zoning in on potential animals that acted as an intermediary host in facilitating SARS-CoV-2’s zoonosis. ....

United States , United Kingdom , Saudi Arabia , Stephen Graham , Angela Betsaidab Laguipo , University Of Cambridge , University Of Cambridge Department Pathology , Pirbright Institute , Temple University , D Weblogo University Of California , Angela Betsaida , Wuhan City , Image Credit , Middle East Respiratory Syndrome , Sars Cov 2 , Amino Acid , Angiotensin Converting Enzyme 2 , Corona Virus , Mers Cov , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , சவுதி அரேபியா , ஸ்டீபன் கிரஹாம் ,

Structure of SARS-CoV-2 cytoplasmic tail uncovered

Structure of SARS-CoV-2 cytoplasmic tail uncovered
The current coronavirus disease 2019 (COVID-19) pandemic has claimed over 1.9 million lives so far, and scientists have been racing to develop vaccines that will curtail its spread. Most of these target the spike (S) protein of the virus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The spike is anchored to the host cell membrane, as it mediates viral binding to the host cell receptor. This is the angiotensin-converting enzyme 2 (ACE2).
The virus s cytosolic tail also interacts with the host cell to promote its entry into the endoplasmic reticulum (ER). A new study appearing on the ....

Liji Thomas , Molecular Recognition Feature , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Cell Membrane , Corona Virus , Coronavirus Disease Covid 19 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , மூலக்கூறு அங்கீகாரம் அம்சம் , செல் சவ்வு , கொரோனா வைரஸ் , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

Researchers pinpoint spike protein regions as targets for passive and active COVID-19 vaccines

Researchers pinpoint spike protein regions as targets for passive and active COVID-19 vaccines
Researchers at Stanford University School of Medicine have identified regions of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that have relatively few mutations and might therefore serve as important targets for prophylactic agents against coronavirus disease 2019 (COVID-19).
Drugs that target these “less variable” regions are more likely to be effective against future variants of SARS-CoV-2 because they remain unchanged or “conserved” as the virus mutates and evolves.
Daria Mochly-Rosen and colleagues identified the regions using a database of almost 190,000 individual virus sequences isolated from patients across the globe, thereby reflecting the natural evolution of the virus. ....

Daria Mochly Rosen , Sally Robertson , Researchers At Stanford University School Of Medicine , Singapore Bioinformatics Institute , Stanford University School , Singapore Bioinformatics , Spike Protein , Amino Acid , Angiotensin Converting Enzyme 2 , Corona Virus , Coronavirus Disease Covid 19 , Sars Cov 2 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , சாலி ராபர்ட்சன் , ஆராய்ச்சியாளர்கள் இல் ஸ்டான்போர்ட் பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்து , சிங்கப்பூர் உயிர் தகவலியல் நிறுவனம் , ஸ்டான்போர்ட் பல்கலைக்கழகம் பள்ளி , சிங்கப்பூர் உயிர் தகவலியல் , ஸ்பைக் ப்ரோடீந் , அமினோ அமிலம் , கொரோனா வைரஸ் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,