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Study suggests T-cells don't determine survival in severe COVID-19


Study suggests T-cells don t determine survival in severe COVID-19
The coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causes mild to moderate illness in the general population. Some people, however, may experience severe symptoms, which can be potentially fatal.
Severe COVID-19 has been tied to T cell lymphopenia, but no causal effect of T cell deficiency on disease severity has been established.
Researchers at the Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health found that T cell-depleted groups of rhesus macaques developed virus-neutralizing antibody responses and also class-switched to immunoglobulin G (IgG). ....

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New nanoparticle SARS-CoV-2 vaccine confers robust protection with single dose after two weeks


New nanoparticle SARS-CoV-2 vaccine confers robust protection with single dose after two weeks
In a methodologically ‘state-of-the-art’ approach, US researchers have developed a protein-based nanoparticle vaccine against coronavirus disease (COVID-19), with a swift generation of antibodies and the potential to protect individuals who cannot receive other COVID-19 vaccines for medical reasons. The research is posted to the
bioRxiv preprint server.
Vaccines currently in use against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a causative agent of COVID-19, focus on the viral spike glycoprotein that mediates cell entry by targeting angiotensin receptor 2 (ACE2) as the main receptor and heparin as the co-receptor. ....

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Ortho signs $53.7M government contract to triple its COVID-19 test production


Apr 5, 2021 11:43am
Backed by BARDA and the Department of Defense, Ortho Clinical Diagnostics is planning to provide up to 6.7 million COVID tests per month by April 2022. (Getty Images)(Circle Creative Studio/iStock/Getty Images Plus/Getty Images)
Vaccination rates may be steadily climbing across the country, but companies hope COVID-19 testing won t slow down any time soon. In fact, manufacturers are now ramping up production of antigen and antibody tests, with Ortho Clinical Diagnostics, for one, expecting to triple its output within the next year.
Ortho’s increased production will be backed by a new contract with the U.S. government s Biomedical Advanced Research and Development Authority, known as BARDA, and a COVID-19 acquisition task force set up by the Air Force. ....

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