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Ark. virus hospitalizations continue decline, reach lowest point since July

LITTLE ROCK, Ark. — The number of people hospitalized with COVID-19 in Arkansas continued falling Friday. ....

United States , Little Rock , Asa Hutchinson , Arkansas Department Of Health , ஒன்றுபட்டது மாநிலங்களில் , கொஞ்சம் பாறை , என ஹட்சின்சன் , ஆர்கன்சாஸ் துறை ஆஃப் ஆரோக்கியம் ,

Experimental safety switch reduces severity of CAR-T immunotherapy-related side effects

Experimental safety switch reduces severity of CAR-T immunotherapy-related side effects
UNC Lineberger Comprehensive Cancer Center researchers have successfully used an experimental safety switch, incorporated as part of a chimeric antigen receptor T-cell (CAR-T) therapy, a type of immunotherapy, to reduce the severity of treatment side effects that sometimes occur. This advance was seen in a patient enrolled in a clinical trial using CAR-T to treat refractory acute B-cell leukemia. It demonstrates a proof-of-principle for possible expanded use of CAR-T immunotherapy paired with the safety switch.
The researchers published their findings in the journal
Blood as an ahead-of-print publication.
With CAR-T therapy, T-cells from a patient s immune system are modified in a manufacturing facility to express part of an antibody that can bind to a surface protein on cancer cells. The modified T-cells, after being infused back into the patient, seek out and attack cancer ce ....

Matthew Foster , Jonathan Serody , Emily Henderson , Lineberger Cellular Immunotherapy Program , Cellular Immunotherapy Program , Lineberger Cellular Therapy Program , School Of Medicine , Bellicum Pharmaceuticals , Lineberger Comprehensive Cancer Center , Comprehensive Cancer Center , Gianpietro Dotti , Cellular Therapy , Acute Lymphoblastic Leukemia , Chimeric Antigen Receptor , Clinical Trial , Immune System , T Cell , மேத்யூ வளர்ப்பு , எமிலி ஹென்டர்சன் , லிநேபேர்கேற் செல்லுலார் நோயெதிர்ப்பு சிகிச்சை ப்ரோக்ர்யாம் , செல்லுலார் நோயெதிர்ப்பு சிகிச்சை ப்ரோக்ர்யாம் , லிநேபேர்கேற் செல்லுலார் சிகிச்சை ப்ரோக்ர்யாம் , பள்ளி ஆஃப் மருந்து , லிநேபேர்கேற் விரிவான புற்றுநோய் மையம் , விரிவான புற்றுநோய் மையம் , செல்லுலார் சிகிச்சை ,

Innovative cancer treatment effective in combating fungal infection in vitro and in mice

Innovative cancer treatment effective in combating fungal infection in vitro and in mice
An innovative cell-based treatment for cancer has been found promising for the control of infections caused by fungi. A study published in the journal
Cytotherapy reports that the use of CAR (chimeric antigen receptor) T-cells programmed to recognize
Cryptococcus spp. fungi was effective in combating infection in vitro and in mice.
C. gattii and
C. neoformans are present in soil with dead organic matter and places contaminated by the droppings of pigeons and other birds. They cause systemic mycoses in the human organism. They can infect the lungs and central nervous system, causing meningitis or meningoencephalitis. The symptoms vary according to the site of the infection, which can be fatal. Transmission occurs by inhalation of the fungi. ....

United States , Bioagents Biocel , Paulo Ribeir , Emily Henderson , Department Of Cellular , Preto Medical School , Dissemination Center , Us Centers For Disease , Drug Administration , Md Anderson Cancer Center , Disease Control , Thiago Aparecido , Molecular Biology , Pathogenic Bioagents , Brazilian Researcher , Young Investigator , Cancer Center , Cell Based Therapy , Cancer Treatment , Cell Wall , Central Nervous System , Chimeric Antigen Receptor , Cryptococcal Meningitis , Immune Response , In Vitro , Nervous System ,

SARS-CoV-2 escapes host immune responses by modulating dendritic cell maturation

SARS-CoV-2 escapes host immune responses by modulating dendritic cell maturation
A team of scientists from Italy and the USA has recently explored the maturation pattern of conventional dendritic cells (cDCs) during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Their findings reveal that the virus efficiently escapes host immune responses by directly interacting with cDCs and disrupting T cell activation. The study is currently available on the
Background
Since its emergence in December 2019 in China, SARS-CoV-2, the causative pathogen of coronavirus disease 2019 (COVID-19), has infected 114 million people and claimed 2.5 million lives worldwide. In its milder form, COVID-19 is mainly associated with fever, dry cough, sore throat etc. However, a severe form of the disease often leads to serious health complications characterized by cardiovascular, pulmonary, and metabolic disorders. In general, COVID-19 patients with severe symptoms exhibit s ....

United States , Sanchari Sinha Dutta , Principal Component Analysis , Coronavirus Disease Covid 19 , Dendritic Cell , Sars Cov 2 , Corona Virus , Metabolic Disorders , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Sore Throat , ஒன்றுபட்டது மாநிலங்களில் , சஞ்சரி சீன்ஹா தத்தா , ப்ரிந்ஸிபல் கூறு பகுப்பாய்வு , கொரோனா வைரஸ் , வளர்சிதை மாற்ற கோளாறுகள் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , புண் தொண்டை ,

Paris-Lamar County Health District reports 1 new Covid-19 death, 8 cases

The Paris-Lamar County Health District has reported one new Covid-19 related death, an 80-year-old woman, bringing the county s total to 110. At the same time, the district reported eight new ....

France General , Lamar County Health District , Paris Lamar County Health District , Paris Lamar County , பிரான்ஸ் ஜநரல் , லாமர் கவுண்டி ஆரோக்கியம் மாவட்டம் , பாரிஸ் லாமர் கவுண்டி ஆரோக்கியம் மாவட்டம் , உயிர் வேதியியல் , பாரிஸ் லாமர் கவுண்டி ,