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MVA SARS-CoV-2 vaccine candidate shows strong immunogenicity in preclinical trials


MVA SARS-CoV-2 vaccine candidate shows strong immunogenicity in preclinical trials
The modified vaccina virus Ankara (MVA) is an attenuated vaccinia virus that has been used as a vector in the already approved Adenovirus-MVA-based Ebola vaccine. A new preprint appearing on the
bioRxiv server reports the preclinical testing of a recombinant MVA (rMVA) candidate vaccine against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent that is causing the current coronavirus disease 2019 (COVID-19) pandemic. The MVA provides a vector platform for the rapid production of such vaccines.
The current study demonstrates the expression of the full-length spike (S) glycoprotein antigen of the SARS-CoV-2 virus by the rMVA. The rMVA-spike-expressing viruses showed efficient replication in the chicken embryo fibroblast cell line DF-1, but not in the human cell lines. ....

Liji Thomas , Middle East , Coronavirus Disease Covid 19 , Sars Cov 2 , Vaccinia Virus , Cell Line , Corona Virus , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , நடுத்தர கிழக்கு , செல் வரி , கொரோனா வைரஸ் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

Could intranasal SARS-CoV-2 vaccines be a practical alternative to intramuscular shots?


Could intranasal SARS-CoV-2 vaccines be a practical alternative to intramuscular shots?
The unchecked advance of the coronavirus disease 2019 (COVID-19) has made it a top public health priority to produce a vaccine capable of inducing a safe and powerful protective response against its causative pathogen: severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). An encouraging new preprint, that appeared on the
bioRxiv server shows the immunogenicity, safety, and protective efficacy, of a Newcastle disease virus (NDV)-based intranasal vector vaccine in animal studies.
A host of candidate vaccines being developed against SARS-CoV-2 use viral vector platforms to present the SARS-CoV-2 spike antigen to the host immune system. Many have used the intramuscular route (i.e., ‘jabs’ or ‘shots’), but the intranasal route allows the development of local or mucosal immunity as well as systemic immunity against the virus. This will allow protection against not just s ....

Liji Thomas , Josep Suria Shutterstock , Drug Administration , Protective Efficacy , Intranasal Live Attenuated Vaccine Against , Preclinical Animal , Image Credit , Josep Suria , Coronavirus Disease Covid 19 , Sars Cov 2 , Corona Virus , Immune System , Public Health , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Viral Vector , படம் கடன் , ஜோசப் சூரியா , கொரோனா வைரஸ் , நோய் எதிர்ப்பு சக்தி அமைப்பு , பொது ஆரோக்கியம் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , வைரஸ் திசையன் ,