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HIV-1C in-House RNA-Based Genotyping Assay for Detection of Drug Resis

HIV-1C in-House RNA-Based Genotyping Assay for Detection of Drug Resistance Mutations in Samples with Low-Level Viral Loads ....

United States , South Africa , Western Cape , South African , Bigdye Xterminator , Abbott Laboratories , Stanford University , Zymo Research , Botswana Combination Prevention Project , Abbott Park , Roche Applied Science , Phusion High Fidelity , Primers Used When Samples Failed , New England Biolabs , Bigdye Terminator , Sequencing Kit , Applied Biosystems , Foster City , Big Dye , Sequencer Version , General Time Reverse , Resistance Database , Calibrated Population Resistance , Clinical Characteristics , Sequencing Success , Saharan Africa ,

Vectorial capacity and TEP1 genotypes of Anopheles gambiae sensu lato mosquitoes on the Kenyan coast | Parasites & Vectors

Malaria remains one of the most important infectious diseases in sub-Saharan Africa, responsible for approximately 228 million cases and 602,000 deaths in 2020. In this region, malaria transmission is driven mainly by mosquitoes of the Anopheles gambiae and, more recently, Anopheles funestus complex. The gains made in malaria control are threatened by insecticide resistance and behavioural plasticity among these vectors. This, therefore, calls for the development of alternative approaches such as malaria transmission-blocking vaccines or gene drive systems. The thioester-containing protein 1 (TEP1) gene, which mediates the killing of Plasmodium falciparum in the mosquito midgut, has recently been identified as a promising target for gene drive systems. Here we investigated the frequency and distribution of TEP1 alleles in wild-caught malaria vectors on the Kenyan coast. Mosquitoes were collected using CDC light traps both indoors and outdoors from 20 houses in Garithe village, along th ....

United States , United Kingdom , Thermomixer Eppendorf , Centers For Disease , Wellcome Trust Research Programme , Kilifi County , Disease Control , Trust Research Programme , Bigdye Terminator , Applied Biosystems , College Station ,

Mammarenaviruses of Rodents, South Africa and Zimbabwe

Mammarenaviruses of Rodents, South Africa and Zimbabwe
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South Africa , United States , Eastern Cape , Trinidad And Tobago , Free State , Nigeria General , Rift Valley , Northern Cape , Merino Walk , Matabeleland South , Sierra Leone , Republic Of South Africa , Centre For Applied Microbiology , Igg Seracare Life Sciences Inc , Princeton Separations Inc , Us Centers For Disease , National Institute For Communicable Diseases , Department Of Health South Africa , Ditsong National Museum Of Natural History Pretoria , Promega Corporation , Biosafety Level , National Institute , Communicable Diseases , Ethics Committee , Thermofisher Scientific , Seracare Life Sciences ,