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New study reveals BA.2.86 subvariant's surprising dance with antibodies

Researchers examined the antigenicity of the emerging SARS-CoV-2 subvariant BA.2.86, finding that it is not resistant to neutralizing antibodies from previously infected or vaccinated individuals, although it does show increased binding affinity to the ACE-2 receptor. The study highlights the subvariant's sensitivity and resistance to different classes of monoclonal antibodies, offering insights for future treatment and vaccine development. ....

United States , Fernando Astasio Avila , Bloom Lab , Coronavirus Disease Covid 19 , Binding Affinity , Monoclonal Antibody , Ars Cov 2 , Evere Acute Respiratory , Evere Acute Respiratory Syndrome ,

Optibrium acquires BioPharmics LLC, expanding its 3D drug design and visualisation offering

Optibrium, a leading developer of software and AI solutions for drug discovery, today announced the acquisition of BioPharmics LLC. ....

United States , San Francisco , Ann Cleves , Matthew Segall , Ajay Jain , University Of California , Optibrium Ltd Aug , University Of Illinois , Harris Pharmaceuticals , Carnegie Mellon University , Iconix Pharmaceuticals , Biopharmics Division , From Optibrium Ltd Aug , Applied Science , Application Science , Computer Science , Carnegie Mellon , Cell Biology , Binding Affinity , Drug Discovery ,

A hybrid approach to re-engineer a SARS-CoV-1 neutralizing antibody against SARS-CoV-2

A hybrid approach involving a combination of conventional discovery and antibody repurposing to combat COVID-19. ....

Alpha Tauri , Science Signaling , Middle East , Ars Cov 2 , Antibody Discovery , Binding Affinity , Cell Sorting , Covid 19 , Ers Cov , Evere Acute Respiratory , Evere Acute Respiratory Syndrome ,

Deep learning framework DeepAIR could improve understanding of adaptive immunity

Researchers presented a deep learning framework, DeepAIR, to accurately predict adaptive immune receptor (AIR)-antigen binding. ....

Protein Data Bank , Science Advances , Corona Borealis , Local Distance Difference Test , Structuralt Cell Receptor Database , Immune Epitope , Critical Assessment , Protein Structure Prediction , Deep Learning , B Cell , Binding Affinity ,

Tumor-derived GDF-15 suppresses immunotherapy response

Researchers evaluate the impact of tumor-derived GDF-15 on responses to anti-PD-1 immunotherapy. ....

Nature Communications , Anti Inflammatory , Binding Affinity , Ell Death , Ctla 4 , Growth Factor , Programmed Cell Death , T Cell ,