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Cryptic pocket on the surface of SARS-CoV-2 may be a promising treatment target

Cryptic pocket on the surface of SARS-CoV-2 may be a promising treatment target
In a new study currently available on the
bioRxiv preprint server, a multinational group of researchers modeled an entire membrane-embedded spike glycoprotein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and highlighted the potential of a specific mapping approach for unveiling cryptic, potentially druggable pockets on the viral surface.
The ongoing global pandemic of coronavirus disease 2019 (COVID-19) has instigated a rapid response in terms of vaccine and drug development targeting the causative agent, SARS-CoV-2. One of its salient targets is the spike glycoprotein, which recognizes the receptor and mediates viral entry into the cell. ....

United Kingdom , Lorena Zuzic , University Of Manchester , Bioinformatics Institute , ஒன்றுபட்டது கிஂக்டம் , பல்கலைக்கழகம் ஆஃப் மான்செஸ்டர் , உயிர் தகவலியல் நிறுவனம் ,

Uniting strengths to expand research

Uniting strengths to expand research
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

Edith Heard , Rayne Zaayman , Giorgio Metta , Italian Institute Of Technology , European Bioinformatics Institute , European Molecular Biology Laboratory , Italian Institute , Rayne Zaayman Gallant , Istituto Italiano , General Edith , Bioinformatics Institute , Scientific Director , எடித் கேள்விப்பட்டேன் , ஜார்ஜியோ மெட்டா , இத்தாலிய நிறுவனம் ஆஃப் தொழில்நுட்பம் , ஐரோப்பிய உயிர் தகவலியல் நிறுவனம் , ஐரோப்பிய மூலக்கூறு உயிரியல் ஆய்வகம் , இத்தாலிய நிறுவனம் , இஸ்டிடூடோ இத்தாலியன் , ஜநரல் எடித் , உயிர் தகவலியல் நிறுவனம் , அறிவியல் இயக்குனர் ,

Researchers identify differences in immune response in asymptomatic versus severe COVID-19 cases

Researchers identify differences in immune response in asymptomatic versus severe COVID-19 cases
news-medical.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from news-medical.net Daily Mail and Mail on Sunday newspapers.

United Kingdom , City Of , Menna Clatworthy , Sarah Teichmann , John Marioni , Emuzlifah Haniffa , Emily Henderson , University College London , Cancer Research United Kingdom Cambridge Institute , Head Of Research , Human Cell Atlas Organizing Committee , Wellcome Sanger Institute , Senior Group Leader , Newcastle University , University Of Cambridge , Wellcome Sanger Institute Associate Faculty , European Bioinformatics Institute , Bioinformatics Institute , Human Cell Atlas , Nature Medicine , Human Cell , Study Senior Author , Senior Clinical Fellow , Wellcome Sanger , Translational Immunology , Molecular Hematology ,

Combating emerging infectious diseases: lessons from COVID-19

Date Time
Combating emerging infectious diseases: lessons from COVID-19
EMBL and Portugal are bringing together leading scientists to highlight the role of fundamental research in tackling infectious diseases
Fundamental research is essential for deepening our understanding of infectious diseases. Credit: Aleksandra Krolik/EMBL
Has any event in modern times highlighted the impact of infectious diseases as starkly as the COVID-19 pandemic? After more than 12 months, it’s hard to remember a moment when issues surrounding infectious diseases have felt more central to all aspects of life.
Scientific infrastructure and sustained research funding play key roles in the global fight against emerging infectious diseases. As part of an initiative implemented by Portugal during its presidency of the Council of the EU, EMBL and Portugal are collaborating to bring together key international experts to address topics such as infectious diseases, immunology, and the molec ....

Aleksandra Krolik , Jeremy Farrar , Manuel Heitor , Edith Heard , Ewan Birney , Sylvie Brian , Pedro Beltrao , Portuguese Ministry Of Research , Department Of Global Infectious Hazard Preparedness , European Bioinformatics Institute , University Of Coimbra , World Health Organization , Emerging Infectious Diseases , General Edith Heard , Portuguese Ministry , Chief Medical Officer , Global Infectious Hazard Preparedness , Wellcome Trust , Director General Ewan , Bioinformatics Institute , Portuguese Minister , ஜெர்மி ஃபரார் , மானுவல் ஹெய்தோர் , எடித் கேள்விப்பட்டேன் , ய்வந் பிர்னி , சில்வி பிரையன் ,

Differing immune responses discovered in asymptomatic cases vs those with severe COVID-19

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The largest study of its type in the UK has identified differences in the immune response to COVID-19, between people with no symptoms, compared to those suffering a more serious reaction to the virus.
Researchers from the Wellcome Sanger Institute, Newcastle University, University College London, University of Cambridge, EMBL s European Bioinformatics Institute (EMBL-EBI) and their collaborators within the Human Cell Atlas initiative, found raised levels of specific immune cells in asymptomatic people. They also showed people with more serious symptoms had lost these protective cell types, but gained inflammatory cells. These differences in the immune response could help explain serious lung inflammation and blood clotting symptoms, and could be used to identify potential targets for developing therapies. ....

United Kingdom , United States , City Of , Emily Stephenson , Menna Clatworthy , Fernandoj Calero Nieto , Michaeld Morgan , Sarah Teichmann , Zewen Kelvin Tuong , Gary Reynolds , Karsten Bach , John Marioni , Aviv Regev , Waradon Sungnak , Rachela Botting , Emuzlifah Haniffa , Research Excellence Framework , University College London , Broad Institute , Cancer Research United Kingdom Cambridge Institute , Head Of Research , Senior Group Leader , Wellcome Sanger Institute Associate Faculty , University Of Cambridge , Newcastle University , European Bioinformatics Institute ,