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Unraveling the mystery of semi-extractable RN

Membraneless organelles in cells contain high concentrations of semi-extractable RNAs, which could serve as potential biomarkers and drug targets. However, the identification and characterization of these RNAs have been limited. Japanese researchers have now developed a novel bioinformatic pipeline to define and analyze semi-extractable RNAs, which has led to the identification of over 1000 RNAs involved in membraneless organelle formation. This study paves the way for future investigations into RNA-centric phase separations. ....

Takeshi Chujo , Michiaki Hamada , Chao Zeng , Tetsuro Hirose , Nucleic Acids Research , Bioinformatics Laboratory , University Computational Bio Big , Data Open Innovation Laboratory , Osaka University , Nippon Medical School , Sustainable Development Goals Sdgs , Molecular Biology Society Of Japan , Institute For , Faculty Of Life Sciences , Kumamoto University , Transdisciplinary Research Initiatives , Method Of Research , School Of Medicine , School Of Frontier Biosciences , Society Of Japan , United Nations , Japanese Society For Bioinformatics Jsbi , Waseda University , Nucleic Acids Research On , Japanese Society Of Bioinformatics Jsbi , National Institute Of Advanced Industrial Science ,