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Neuropeptide released by pain neurons promotes wound healing by interacting with immune system

Wound healing is a highly specialized dynamic process for the repair of damaged/injured tissues through an intricate mechanism. Any failure in the normal wound healing process results in abnormal scar formation, and a chronic state which is more susceptible to infections. Researchers from Monash University in Australia and Osaka University in Japan have demonstrated that the removal of a specific subtype of sensory neurons containing the Nav1.8+ ion channel significantly impairs skin wound repair and muscle regeneration following injury. ....

South Australia , Monash University , Osaka University , Bioworld Science , Calcitonin Gene Related Peptide , Wound Healing , Neurology Psychiatric ,

AACR 2024: New concepts suggest new targets for metastatic disease

Prior to this year’s Annual Meeting of the American Association for Cancer Research (AACR), it had been 14 years since metastasis had been the subject of a plenary session. So, the Tuesday session on “Evolution of the genome, microenvironment, and host through metastasis” had plenty of new insights to share. ....

United States , Annual Meeting , American Association , Cancer Research , Bioworld Science , Weill Cornell Medical College , Memorial Sloan Kettering Cancer Center , Aacr 2024 , American Association For Cancer Research ,

Australian scientists explore MERTK as a target against organ fibrosis

A small molecule could provide a new therapeutic approach against organ fibrosis. Using genome-wide association (GWA) assays, a group of researchers of the Westmead Institute for Medical Research in Sydney identified Mer tyrosine kinase (MERTK) as a candidate to study fibrosis and showed that its inhibition with the experimental compound reduced this condition in mouse models’ liver, kidneys and lungs. ....

New South Wales , Mohammed Eslam , Westmead Institute For Medical Research , Westmead Institute , Medical Research , Bioworld Science , Endocrine Metabolic , Idiopathic Pulmonary Fibrosis , Liver Fibrosis , Kidney Fibrosis , Unc 569 ,

AACR 2024: Getting older younger may be driving rise in early-onset cancers

As with most common diseases of the developed world, aging is the major risk factor for developing cancer. Most of the half-dozen hallmarks of precancer that were published last week by investigators from Vanderbilt University and the Fred Hutchinson Cancer Research Center are also hallmarks of aging.
Unfortunately, scientists reported at the American Association for Cancer Research’s (AACR) 2024 annual meeting this week that accelerated aging is increasing, and may be driving an increase in early-onset cancers. ....

United States , Vanderbilt University , Fred Hutchinson Cancer Research Center , American Association For Cancer Research , American Association , Cancer Research , Bioworld Science , Hallmarks Of Cancer , Aacr 2024 , Accelerated Aging ,

Aging, and aging well, gives clues for dementia drug discovery

Ironically, the first person to be diagnosed with what is now Alzheimer’s disease was missing its major risk factor. When she first began showing symptoms of dementia in 1901, Auguste Deter was not particularly old. Despite Deter’s case, aging is the largest risk factor for developing Alzheimer’s, by a large margin. But “geroscience has not been translated into drugs for Alzheimer’s disease,” Howard Fillit, Alzheimer’s Drug Discovery Foundation co-founder and chief scientific officer, told BioWorld. “We’re just starting to see that cross-fertilization now.” This first article of a three-part BioWorld series on Alzheimer’s disease looks at how a group of researchers, as well as some startups, are trying to approach Alzheimer’s via an aging lens. ....

Howard Fillit , Auguste Deter , Alzheimer Drug Discovery Foundation , Drug Discovery Foundation , Bioworld Science , Alzheimers Disease , Neuroage Therapeutics Inc , Neurology Psychiatric ,