Unraveling the mystery of misfolded proteins in the brain
Proteins known as oligomeric chaperones help suppress the formation of misshaped proteins that cause a variety of degenerative and neurodegenerative diseases, s
Source: newswise.com
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Computational approach used to understand the mechanisms of protein folding in tauopathies
A team at UT Southwestern has developed a computational approach to uncover mechanisms of protein misfolding linked to neurodegenerative diseases.
Source: news-medical.net
Bringing bad proteins back into the fold
Credit: UT Southwestern Medical Center DALLAS - Feb. 11, 2021 - A study led by UT Southwestern has identified a mechanism that controls the activity of proteins known as chaperones, which guide proteins to fold into the right shapes. The findings, published online today in Nature Communications, could shed light on hundreds of degenerative and neurodegenerative diseases caused by protein misfolding, such as Alzheimer's, Parkinson's, and Huntington's, potentially leading to new treatments for these devastating conditions. Every protein in the body is originally produced in a linear chain, wit...
Source: eurekalert.org