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United States , Chryshanthi Joseph , Genevieve Konopka , Kyung Kim , Byeongha Jeong , Loydb Sands , Michaele Greenberg , Peter Odonnell Jr , Josephs Takahashi , Ashwinikumar Kulkarni , Kimberlyh Cox , Odonnell Brain Institute , Jon Heighten Scholar In Autism Research , National Institutes Of Health , Harvard Medical School , Howard Hughes Medical Institute Investigator , Chan Zuckerberg Initiative , National Academy Of Medicine , National Academy Of Sciences , Ut Southwestern Medical Center , Brain Institute , Jamess Mcdonnell Foundation , Century Science Initiative In Understanding Human Cognition , Silicon Valley Community Foundation , Howard Hughes Medical Institute Investigators , Howard Hughes Medical Institute ,

Genomic study identifies marked differences between two halves of the hippocampus

A study of gene activity in the brain's hippocampus, led by UT Southwestern researchers, has identified marked differences between the region's anterior and posterior portions. The findings, published today in Neuron, could shed light on a variety of brain disorders that involve the hippocampus and may eventually help lead to new, targeted treatments. ....

Genevieve Konopka , Peter Odonnell Jr , Emily Henderson , Ut Southwestern Medical Center , Jon Heighten Scholar In Autism Research , Brain Institute , Study Leader , Associate Professor , Jon Heighten Scholar , Autism Research , Petero Donnell , ஜெநிவீவ் கோனோப்கா , பீட்டர் ஓடொன்னேழில் ஜூனியர் , எமிலி ஹென்டர்சன் , உட் தென்மேற்கு மருத்துவ மையம் , மூளை நிறுவனம் , படிப்பு தலைவர் , இணை ப்ரொஃபெஸர் , மன இறுக்கம் ஆராய்ச்சி ,

Same difference: Two halves of the hippocampus have different gene activity

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IMAGE: Marked differences in gene activity were identified in the anterior portion of the hippocampus, which points downward toward the face, and the posterior, which points upward toward the back of.
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Credit: Melissa Logies
DALLAS - May 28, 2021 - A study of gene activity in the brain s hippocampus, led by UT Southwestern researchers, has identified marked differences between the region s anterior and posterior portions. The findings, published today in
Neuron, could shed light on a variety of brain disorders that involve the hippocampus and may eventually help lead to new, targeted treatments.
These new data reveal molecular-level differences that allow us to view the anterior and posterior hippocampus in a whole new way, says study leader Genevieve Konopka, Ph.D., associate professor of neuroscience at UTSW. ....

United States , University Of Texas , Karthigayini Sivaprakasam , Genevieve Konopka , Connor Douglas , Peter Odonnell Jr , Fatma Ayhan , Ashwinikumar Kulkarni , Jon Heighten Scholar In Autism Research , National Center , National Institutes Of Health , Chan Zuckerberg Initiative , Translational Sciences , Brain Institute , Jamess Mcdonnell Foundation , Silicon Valley Community Foundation , Century Science Initiative In Understanding Human Cognition , Chilton Foundation , Jon Heighten Scholar , Autism Research , Petero Donnell , Stefano Berto , National Institutes , Advancing Translational Sciences , Translational Medicine , Odonnell Foundation ,

Scientists identify source of weight gain from antipsychotics

Credit: UT Southwestern Medical Center
DALLAS - May 12, 2021 - Scientists with UT Southwestern s Peter O Donnell Jr. Brain Institute have identified the molecular mechanism that can cause weight gain for those using a common antipsychotic medication. The findings, published in the
Journal of Experimental Medicine, suggest new ways to counteract the weight gain, including a drug recently approved to treat genetic obesity, according to the study, which involved collaborations with scientists at UT Dallas and the Korea Advanced Institute of Science and Technology.
If this effect can be shown in clinical trials, it could give us a way to effectively treat patients for their neuropsychiatric conditions without this serious side effect, says lead author Chen Liu, Ph.D., assistant professor of internal medicine and neuroscience, and with UTSW s O Donnell Brain Institute and Hypothalamic Research Center. ....

South Korea , United States , Amandag Arnold , Sharig Birnbaum , Lin Jia , Stevenc Wyler , Xiameng Chen , Peter Odonnell Jr , Xiujuan Li , Eun Seon Yoo , Chen Liu , Brain Institute , Korean National Research Foundation , National Institutes Of Health , Utsw Odonnell Brain Institute , Hypothalamic Research Center , Drug Administration , Korea Advanced Institute Of Science , Petero Donnell , Experimental Medicine , Korea Advanced Institute , Odonnell Brain Institute , Hypothalamic Research , National Institutes , Rong Wan , Jong Woo Sohn ,

Scientists identify molecular mechanism behind weight gain in patients taking antipsychotics

Scientists identify molecular mechanism behind weight gain in patients taking antipsychotics
Scientists with UT Southwestern s Peter O Donnell Jr. Brain Institute have identified the molecular mechanism that can cause weight gain for those using a common antipsychotic medication. The findings, published in the Journal of Experimental Medicine, suggest new ways to counteract the weight gain, including a drug recently approved to treat genetic obesity, according to the study, which involved collaborations with scientists at UT Dallas and the Korea Advanced Institute of Science and Technology.
If this effect can be shown in clinical trials, it could give us a way to effectively treat patients for their neuropsychiatric conditions without this serious side effect. ....

South Korea , Peter Odonnell Jr , Emily Henderson , Chen Liu , Brain Institute , Hypothalamic Research Center , Drug Administration , Utsw Odonnell Brain Institute , Korea Advanced Institute Of Science , Petero Donnell , Experimental Medicine , Korea Advanced Institute , Odonnell Brain Institute , Hypothalamic Research , தெற்கு கொரியா , பீட்டர் ஓடொன்னேழில் ஜூனியர் , எமிலி ஹென்டர்சன் , சென் லியூ , மூளை நிறுவனம் , சோதனை மருந்து , டோனெல் மூளை நிறுவனம் ,