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Frontiers | GPX7 Is Targeted by miR-29b and GPX7 Knockdown Enhances Ferroptosis Induced by Erastin in Glioma

Background Glioma is a lethal primary tumor of central nervous system. Ferroptosis is a newly identified form of necrotic cell death. Triggering ferroptosis has shown potential to eliminate aggressive tumors. GPX7, a member of glutathione peroxidase family (GPXs), has been described to participate in oxidative stress and tumorigenesis. However, the biological functions of GPX7 in glioma are still unknown. Methods Bioinformatics method was used to assess the prognostic role of GPX7 in glioma. CCK8, wound healing, transwell and cell apoptosis assays were performed to explore the functions of GPX7 in glioma cells. In vivo experiment was also conducted to confirm in vitro findings. Ferroptosis-related assays were carried out to investigate the association between GPX7 and ferroptosis in glioma. Results GPX7 was aberrantly expressed in glioma and higher expression of GPX7 was correlated with adverse outcomes. GPX7 silencing enhanced ferroptosis-related oxidative stress in glioma cells and t ....

United States , United Kingdom , Dunfa Peng , Biochim Biophys Acta , Silva Mcda , Chin Neurosurg , Duttaa Micrornas , Liuy Erastin , Zheng Chen , Extensive Network , Huanhu Hospital Department Of Neurosurgery , Beina Chuanglian Biotechnology Institute , Dojindo Molecular Technology , Sunz Global Research Trends Of Ferroptosis , Cell Bioscience Inc , Committee Of Tianjin Huanhu Hospital , National Natural Science Foundation Of China , Sibeifu Beijing Biotechnology Co , Jackson Immunoresearch Inc , Pathology Department Of Huanhu Hospital , Detection Kit Solarbio Co , Technology Commission , Implications For Cancer Development , Chinese Glioma Genome Atlas , Cancer Genome Atlas , Gene Expression Ominibus ,

Detailed text transcripts for TV channel - CNN - 20180329:12:44:00

About soy s health claims. are soy foods really good for you? it depends on the benefits you are looking for and how they are prepared. soy is naturally low in saturated fat. and high in fiber and healthy fats. recently the fda proposed revoking a claim that soy can reduce your risk for heart disease. citing inconsistent findingsen about health experts say eating soy instead much red meat may lower levels of bad ldl to a small september. as for breast health, they stain plant estrogens and some studies show those chemicals can stimulate cancer cell growth. but one study says soy may decrease breast cancer risk. overall soy is a good source of plant based protein, but experts warn processed soy doesn t offer the same health benefits of natural soy foods. so stick to natural sources such as soy nuts. (siren wailing) ....

Health Claims , Heart Disease , Health Experts , Eating Soy , Red Meat , Breast Health , Breast Cancer Risk , Cancer Cell Growth , Plant Estrogens , Small September , Soy Doesn T , Soy Foods , Soy Nuts , Siren Wailing ,

Detailed text transcripts for TV channel - FOXNEWS - 20151020:09:17:00

A new study show women with the disease who had high levels of fish in their diets were one-third less likely to die prematurely. women who had the highest intake of fresh tuna had a 29% lower risk of dying than those who did not eat fish. researchers believe that fatty acids in the fish have anti-inflammatory effects and may reduce cancer cell growth. do you think you have a lot in common with your significant other? i m so glad we re finally doing this. me, too. here. well, it turns out there s a reason for that. a recent study says that we are likely to subconsciously pick a partner with similar genes and an vestry. very interesting. opposite of what we ve always heard. the time now is 17 after the top of the hour and first the director of the cia and now the director of homeland security hacked by a high schooler. how does that happen? an one dad s hilarious ....

Significant Other , Cancer Cell Growth , Fatty Acids , Homeland Security ,