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Novel gene-editing strategy harnesses an unusual protective ability to eliminate HIV-1 infection

Genetic alterations that give rise to a rare, fatal disorder known as MOGS-CDG paradoxically also protect cells against infection by viruses.

San-francisco , California , United-states , Thomasj-cradick , Conradry-cruz , Shuren-liao , Chen , Kamel-khalili , Shohreh-amini , Laurah-carnell , Catherinem-bollard , James-dressman

Brentuximab in Pediatric HL: 'Paradigm Shift' and Just Approved

Adding brentuximab vedotin to chemotherapy in pediatric Hodgkin lymphoma produced results that have been hailed as a 'paradigm shift' and have just led to FDA approval for this new indication.

New-york , United-states , Georgia , Massachusetts , Atlanta , Washington , Boston , Maryland , Emory-university-school-of-medicine , Sharon-castellino , Kara-kelly , Angelam-feraco

Brentuximab vedotin regimen lowers relapse risk in pediatric high-risk Hodgkin lymphoma

The addition of first-line brentuximab vedotin to chemotherapy reduced risk for relapse compared with standard treatment among pediatric patients with high-risk Hodgkin lymphoma, according to study results. The findings, published in The New England Journal of Medicine, additionally showed the brentuximab vedotin (Adcetris, Seagen) regimen to be well tolerated.

Sharonm-castellino , Catherinem-bollard , Mark-roschewski , Blood-disorders-center , Children-oncology-group , Emory-university-school-of-medicine , National-cancer-trials-network-cooperative-group , Winship-cancer-institute-of-emory-university , Cancer-research , Children-national-research-institute-center , Immunology-research , New-england-journal