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Severe influenza A virus (IAV) infections can result in hyper-inflammation, lung injury and acute respiratory distress syndrome1–5 (ARDS), for which there are no effective pharmacological therapies. Necroptosis is an attractive entry point for therapeutic intervention in ARDS and related inflammatory conditions because it drives pathogenic lung inflammation and lethality during severe IAV infection6–8 and can potentially be targeted by receptor interacting protein kinase 3 (RIPK3) inhibitors. Here we show that a newly developed RIPK3 inhibitor, UH15-38, potently and selectively blo...

Type 2 diabetes mellitus (T2D), a major cause of worldwide morbidity and mortality, is characterized by dysfunction of insulin-producing pancreatic islet β cells1,2. T2D genome-wide association studies (GWAS) have identified hundreds of signals in non-coding and β cell regulatory genomic regions, but deciphering their biological mechanisms remains challenging3–5. Here, to identify early disease-driving events, we performed traditional and multiplexed pancreatic tissue imaging, sorted-islet cell transcriptomics and islet functional analysis of early-stage T2D and control donors....

The "Europe Single Cell Multiomics Market 2021-2031 by Product Type, Omics Type, Application, Sample Type, Workflow, End User, and Country: Trend Forecast and Growth Opportunity" report has been added

/PRNewswire/ -- The "North America Single Cell Multiomics Market 2021-2031 by Product Type, Omics Type, Application, Sample Type, Workflow, End User, and...

DUBLIN--(BUSINESS WIRE)--The "Asia Pacific Single Cell Multiomics Market 2021-2031 by Product Type, Omics Type, Application, Sample Type, Workflow, End User, and Country: Trend Forecast and Growth Opportunity" report has been added to ResearchAndMarkets.com's offering.Asia Pacific single cell multiomics market will...