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Marina Wainstein and colleagues examine acute kidney injury (AKI) incidence, severity, and outcomes among patients with COVID-19 using both a traditional and extended definition of AKI.
In a cohort study, Jessica Gong and colleagues investigate associations between reproductive factors, number of children, and dementia among individuals in the UK Biobank.
Mireille Captieux and co-workers report on population-level evidence for remission of type 2 diabetes in Scotland.
Abstract While it is now widely accepted that host inflammatory responses contribute to lung injury, the pathways that drive severity and distinguish coronavirus disease 2019 (COVID-19) from other viral lung diseases remain poorly characterized. We analyzed plasma samples from 471 hospitalized patients recruited through the prospective multicenter ISARIC4C study and 39 outpatients with mild disease, enabling extensive characterization of responses across a full spectrum of COVID-19 severity. Progressive elevation of levels of numerous inflammatory cytokines and chemokines (including IL-6, CXC...