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WHO Collaborating Centre highlights the power of modelling for infectious disease prevention and control - World

WHO Collaborating Centre highlights the power of modelling for infectious disease prevention and control - World
reliefweb.int - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from reliefweb.int Daily Mail and Mail on Sunday newspapers.

London , City-of , United-kingdom , Congo , Guinea , Nahoko-shindo , Richard-pebody , Azra-ghani , Vaccine-impact-modelling-consortium , Centre-for-global-infectious-disease-analysis , International-health-regulations-emergency-committee , Imperial-college-london

Use of an extended KDIGO definition to diagnose acute kidney injury in patients with COVID-19: A multinational study using the ISARIC–WHO clinical characterisation protocol

Marina Wainstein and colleagues examine acute kidney injury (AKI) incidence, severity, and outcomes among patients with COVID-19 using both a traditional and extended definition of AKI.

Norway , New-york , United-states , Australia , United-kingdom , Washington , Brazil , Dublin , Ireland , Canada , India , Italy

A prenylated dsRNA sensor protects against severe COVID-19

A prenylated dsRNA sensor protects against severe COVID-19
science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.

Peru , United-kingdom , Germany , Neanderthal , Nordrhein-westfalen , Nigeria , Bern , Switzerland , Lima , Cambridge , Cambridgeshire , London

Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19

Abstract
While it is now widely accepted that host inflammatory responses contribute to lung injury, the pathways that drive severity and distinguish coronavirus disease 2019 (COVID-19) from other viral lung diseases remain poorly characterized. We analyzed plasma samples from 471 hospitalized patients recruited through the prospective multicenter ISARIC4C study and 39 outpatients with mild disease, enabling extensive characterization of responses across a full spectrum of COVID-19 severity. Progressive elevation of levels of numerous inflammatory cytokines and chemokines (including IL-6, CXCL10, and GM-CSF) were associated with severity and accompanied by elevated markers of endothelial injury and thrombosis. Principal component and network analyses demonstrated central roles for IL-6 and GM-CSF in COVID-19 pathogenesis. Comparing these profiles to archived samples from patients with fatal influenza, IL-6 was equally elevated in both conditions whereas GM-CSF was prominent only in COVID-19. These findings further identify the key inflammatory, thrombotic, and vascular factors that characterize and distinguish severe and fatal COVID-19.

United-kingdom , United-states , Rockville , Maryland , Massachusetts , Minnesota , California , London , City-of , La-jolla , Edinburgh , Scotland