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Four scientists from Barcelona have created the first map of the vulnerable sites of the KRAS gene, whose mutations, often associated with smoking, cause millions of tumors
Scientists stated that the KRAS gene has been historically considered ‘undruggable’ since it was first discovered in 1982.
<p>Researchers have comprehensively identified the allosteric control sites found in the protein KRAS. These are highly sought after targets for drug development, representing secret vulnerabilities which can be exploited to control the effects of one of the most important causes of cancer. The study, published in Nature, presents the first complete control map for any protein and is expected to greatly accelerate the discovery of safer, more effective cancer treatments.</p>