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Single-cell profiling of human bone marrow progenitors reveals mechanisms of failing erythropoiesis in Diamond-Blackfan anemia

Single-cell profiling of human bone marrow progenitors reveals mechanisms of failing erythropoiesis in Diamond-Blackfan anemia
science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.

Eteläuomen Läi , Perifereia Dytikis Elladas , United Kingdom , City Of , Shandon Cytospin , Miltenyi Biotec , Blood Cancer United Kingdom Clinical Research Fellowship , National Research Ethics Committee , National Institute Of Diabetes , Miltenyi Biotec Ltd , Academy Of Medical Sciences Starter Grant , Imperial College Healthcare , National Human Genome Research Institute Intramural , United Kingdom Research Award , British Society Of Haematology Early Stage , Imperial College London , John Goldman Centre For Cellular Therapy , Brilliant Violet , Dead Fixable Stain , Tree Star , Annexinv Binding Buffer , Supplementary Materials , Chromium Single Cell , Gel Bead Kits , National Institutes , Thermo Fisher Scientific ,

Integrated single-cell analysis unveils diverging immune features of COVID-19, influenza, and other community-acquired pneumonia

Integrated single-cell analysis unveils diverging immune features of COVID-19, influenza, and other community-acquired pneumonia
elifesciences.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from elifesciences.org Daily Mail and Mail on Sunday newspapers.

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Activation of Sympathetic Signaling in Macrophages Blocks Systemic Inflammation and Protects against Renal Ischemia-Reperfusion Injury

Activation of Sympathetic Signaling in Macrophages Blocks Systemic Inflammation and Protects against Renal Ischemia-Reperfusion Injury
asnjournals.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from asnjournals.org Daily Mail and Mail on Sunday newspapers.

New York , United States , United Kingdom , Baden Wüberg , Bergisch Gladbach , Nordrhein Westfalen , Masaomi Nangaku , Rieko Matsuda , Miltenyi Biotec , Naoki Kuramoto , Hirokir Ueda , Toshiyuki Ko , Tanabe Ea Susaki , Etsuoa Susaki , Atsuko Nakanishi Ozeki , Shintaro Yamada , Imaris Bitplane , Yu Hirata , Daichi Fukaya , Takashi Taguchi , Issei Komuro , Youichiro Wada , Tsuyoshi Inoue , Wachirasek Peerapanyasut , Sayaka Hayashi , Seitaro Nomura ,

Cardiac cell type–specific gene regulatory programs and disease risk association

Misregulated gene expression in human hearts can result in cardiovascular diseases that are leading causes of mortality worldwide. However, the limited information on the genomic location of candidate cis-regulatory elements (cCREs) such as enhancers and promoters in distinct cardiac cell types has restricted the understanding of these diseases. Here, we defined >287,000 cCREs in the four chambers of the human heart at single-cell resolution, which revealed cCREs and candidate transcription factors associated with cardiac cell types in a region-dependent manner and during heart failure. We further found cardiovascular disease–associated genetic variants enriched within these cCREs including 38 candidate causal atrial fibrillation variants localized to cardiomyocyte cCREs. Additional functional studies revealed that two of these variants affect a cCRE controlling KCNH2/HERG expression and action potential repolarization. Overall, this atlas of human cardiac cCREs provides the found ....

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The Role of Astrocytes in Neurodegenerative Disease

Shane Liddelow, PhD

Dr. Liddelow explains how he and his team approached their research, including the initial questions they set out to answer, the roadblocks they encountered, and how they discovered a neurotoxic form of reactive astrocytes. Shane and his team set out to study the interactions between astrocytes and neurons, hoping to better comprehend the functional roles of astrocytes in a range of neurodegenerative diseases.
Watch this webinar to discover:
How astrocyte function changes over time at different stages of disease initiation and progression
How Chromium Single Cell and Visium Spatial Gene Expression can be used to analyze neurodegenerative disease ....

Chromium Single Cell , Visium Spatial Gene Expression , குரோமியம் ஒற்றை செல் ,