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Association between antidementia medication use and mortality in people diagnosed with dementia with Lewy bodies in the UK: A retrospective cohort study

Author summary Why was this study done? Compared to Alzheimer’s disease (AD), dementia with Lewy bodies (DLBs) is associated with accelerated cognitive decline, lower quality of life, higher caregiver burden, shorter lifespan, and higher costs of care, as well as increased rates of admission to general hospitals and residential care and longer length of stay. Although there are no disease-modifying medications for DLB, there is evidence suggesting that acetylcholinesterase inhibitors (AChEIs) and glutamate N-methyl-D-aspartate receptor antagonists (specifically, memantine) are efficacious in DLB, though an impact on mortality is not clear. Distinct evidence on any survival benefit of AChEIs and memantine in DLB needs to be explored specifically, as DLB is pathologically and clinically different from AD and other forms of dementia. What did the researchers do and find? We identified 592 patients with DLB, including 219 who never took AChEIs or memantine, 100 who took AChEIs ....

United Kingdom , United Kingdom National Health Service , Research Ethics , United Kingdom Confidentiality Advisory Group , International Classification Of Diseases , United Kingdom National Institute For Health , Health Of The Nation Outcomes Scales , World Health Organization , Foundation Trust , British Association For Psychopharmacology , Health Problems , Hospital Episode Statistics , Coronavirus Disease , International Classification , Related Health Problems , United Kingdom National Institute , Care Excellence , Multiple Deprivation , Mini Mental State Examination , Montreal Cognitive Assessment , Cognitive Examination , Nation Outcomes Scales , United Kingdom National Health Service Act , British Association , Alzheimers Disease , Medical Risk Factors ,

Association between antidementia medication use and mortality in people diagnosed with dementia with Lewy bodies in the UK: A retrospective cohort study

Author summary Why was this study done? Compared to Alzheimer’s disease (AD), dementia with Lewy bodies (DLBs) is associated with accelerated cognitive decline, lower quality of life, higher caregiver burden, shorter lifespan, and higher costs of care, as well as increased rates of admission to general hospitals and residential care and longer length of stay. Although there are no disease-modifying medications for DLB, there is evidence suggesting that acetylcholinesterase inhibitors (AChEIs) and glutamate N-methyl-D-aspartate receptor antagonists (specifically, memantine) are efficacious in DLB, though an impact on mortality is not clear. Distinct evidence on any survival benefit of AChEIs and memantine in DLB needs to be explored specifically, as DLB is pathologically and clinically different from AD and other forms of dementia. What did the researchers do and find? We identified 592 patients with DLB, including 219 who never took AChEIs or memantine, 100 who took AChEIs ....

United Kingdom , United States , City Of , Jonathan Lewis , United Kingdom National Health Service , Research Ethics , United Kingdom Confidentiality Advisory Group , International Classification Of Diseases , United Kingdom National Institute For Health , Health Of The Nation Outcomes Scales , World Health Organization , Foundation Trust , British Association For Psychopharmacology , Department Of Health , Health Problems , Hospital Episode Statistics , Coronavirus Disease , International Classification , Related Health Problems , United Kingdom National Institute , Care Excellence , Multiple Deprivation , Mini Mental State Examination , Montreal Cognitive Assessment , Cognitive Examination , Nation Outcomes Scales ,

A Simple Urine Test for Alzheimer's Disease? | Technology Networks

A new study published in Frontiers in Aging Neuroscience identifies formic acid as a potential biomarker for early-stage Alzheimer’s disease. Obtained from urine, the biomarker could offer an inexpensive and efficient diagnostic tool for the neurodegenerative condition. ....

Aging Neuroscience , Mini Mental State Examination , Cognitive Examination , Montreal Cognitive Assessment Basic ,

Cognitive Ability Influenced by Factors Throughout Lifetime

An intellectually enriching lifestyle can moderate the association between childhood cognitive ability and cognitive state in later life. ....

Pamela Almeida Meza , University College London , National Adult Reading Test , Healthday News , Cognitive Examination ,

Cognitive Ability Influenced by Factors Throughout Lifetime

An intellectually enriching lifestyle can moderate the association between childhood cognitive ability and cognitive state in later life. ....

Pamela Almeida Meza , University College London , National Adult Reading Test , Healthday News , Cognitive Examination ,