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Anti-Adhesion Products Market Projected to Reach $1.69 billion by 2030 - Exclusive Report by 360iResearch

Anti-Adhesion Products Market Projected to Reach $1.69 billion by 2030 - Exclusive Report by 360iResearch
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Phoenix , Arizona , United-states , Pune , Maharashtra , India , United-kingdom , China , Ketan-rohom , Adhesion-solutions , Office-no , Research-methodology

Effect of combination treatment with glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors on incidence of cardiovascular and serious renal events: population based cohort study

Objective To determine whether the combined use of glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose cotransporter-2 (SGLT-2) inhibitors is associated with a decreased risk of major adverse cardiovascular events and serious renal events compared with either drug class alone among patients with type 2 diabetes, and to assess the effect of the combination on the individual components of major adverse cardiovascular events, heart failure, and all cause mortality.

Design Population based cohort study using a prevalent new-user design, emulating a trial.

Setting UK Clinical Practice Research Datalink linked to Hospital Episode Statistics Admitted Patient Care and Office for National Statistics databases.

Participants Two prevalent new-user cohorts were assembled between January 2013 and December 2020, with follow-up until the end of March 2021. The first cohort included 6696 patients who started GLP-1 receptor agonists and added on SGLT-2 inhibitors, and the second included 8942 patients who started SGLT-2 inhibitors and added on GLP-1 receptor agonists. Combination users were matched, in a 1:1 ratio, to patients prescribed the same background drug, duration of background drug, and time conditional propensity score.

Main outcome measures Cox proportional hazards models were fitted to estimate the hazard ratios and 95% confidence intervals of major adverse cardiovascular events and serious renal events, separately, comparing the GLP-1 receptor agonist-SGLT-2 inhibitor combination with the background drug, either GLP-1 receptor agonists or SGLT-2 inhibitors, depending on the cohort. Secondary outcomes included associations with the individual components of major adverse cardiovascular events (myocardial infarction, ischaemic stroke, cardiovascular mortality), heart failure, and all cause mortality.

Results Compared with GLP-1 receptor agonists, the SGLT-2 inhibitor-GLP-1 receptor agonist combination was associated with a 30% lower risk of major adverse cardiovascular events (7.0 v 10.3 events per 1000 person years; hazard ratio 0.70, 95% confidence interval 0.49 to 0.99) and a 57% lower risk of serious renal events (2.0 v 4.6 events per 1000 person years; hazard ratio 0.43, 0.23 to 0.80). Compared with SGLT-2 inhibitors, the GLP-1 receptor agonist-SGLT-2 inhibitor combination was associated with a 29% lower risk of major adverse cardiovascular events (7.6 v 10.7 events per 1000 person years; hazard ratio 0.71, 0.52 to 0.98), whereas serious renal events generated a wide confidence interval (1.4 v 2.0 events per 1000 person years; hazard ratio 0.67, 0.32 to 1.41). Secondary outcomes generated similar results but with wider confidence intervals.

Conclusions In this cohort study, the GLP-1 receptor agonist-SGLT-2 inhibitor combination was associated with a lower risk of major adverse cardiovascular events and serious renal events compared with either drug class alone.

This study is based on data from the Clinical Practice Research Datalink obtained under license from the UK Medicines and Healthcare products Regulatory Agency. The data are provided by patients and collected by the UK National Health Service as part of their care and support. The interpretation and conclusions contained in this study are those of the authors alone. Because electronic health records are classified as “sensitive data” by the UK Data Protection Act, information governance restrictions (to protect patient confidentiality) prevent data sharing via public deposition. Data are available with approval, through the individual constituent entities controlling access to the data. Specifically, the primary care data can be requested via application to the Clinical Practice Research Datalink (<https://www.cprd.com>).

United-kingdom , Bristol , City-of , Montreal , Quebec , Canada , Canadian , British , Canadian-institutes-of-health-research , Novartis , Setting-united-kingdom-clinical-practice-research-datalink

Hong Kongers In The UK: The Hard Part About Political Asylum

Hong Kongers In The UK: The Hard Part About Political Asylum
worldcrunch.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from worldcrunch.com Daily Mail and Mail on Sunday newspapers.

City-of-london , London , City-of , United-kingdom , Hong-kong , China , British , Chinese , Hong-konger , Hong-kongers , Hong-kong-bnos , Zheng-jialang

Scientists urged to collect royalties from the 'magic money tree'

By joining a collecting society, researchers can ensure they are paid when copyrighted book content and papers are reproduced. By joining a collecting society, researchers can ensure they are paid when copyrighted book content and papers are reproduced.

Cambridge , Cambridgeshire , United-kingdom , Argentina , Canada , United-states , Australia , Michigan , Buenos-aires , Distrito-federal , Australian , American

Hospitals take scalpel to waste as health sector's carbon footprint is double that of aviation

Hospitals take scalpel to waste as health sector's carbon footprint is double that of aviation
abc.net.au - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from abc.net.au Daily Mail and Mail on Sunday newspapers.

Coffs-harbour , New-south-wales , Australia , United-kingdom , Melbourne , Victoria , Nick-watts , James-carmody , Brian-oconnell , National-university-of-singapore , United-kingdom-national-health-service , Centre-for-sustainable-medicine

Australia, UK, and US Join Forces to Decarbonise Global Healthcare

Australia, UK, and US Join Forces to Decarbonise Global Healthcare
theepochtimes.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from theepochtimes.com Daily Mail and Mail on Sunday newspapers.

Australia , United-states , Norway , Ireland , Melbourne , Victoria , Switzerland , Dubai , Dubayy , United-arab-emirates , United-kingdom , Canada

Immersive Labs Announces Inaugural Cyber Drills Roadshow to Give Organizations the Human Edge Against Threats

Immersive Labs Announces Inaugural Cyber Drills Roadshow to Give Organizations the Human Edge Against Threats
streetinsider.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from streetinsider.com Daily Mail and Mail on Sunday newspapers.

New-york , United-states , United-kingdom , Chicago , Illinois , Bristol , City-of , Munich , Bayern , Germany , London , America

ActiveOps sales up; Sancus turnover jumps

The following is a round-up of trading updates by London-listed companies, issued on Wednesday and not separately reported by Alliance News:
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Neometals Ltd - London-based battery materials...

United-kingdom , Chepstow , Monmouthshire , Germany , Ireland , Ghana , London , City-of , Ghanaian , Irish , Richard-jeffery , Neil-herbert

Skyports raises million$$$+ – SatNews

Skyports raises million$$$+ – SatNews
satnews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from satnews.com Daily Mail and Mail on Sunday newspapers.

United-kingdom , Lima , Peru , Paris , France-general- , France , Dubai , Dubayy , United-arab-emirates , New-york , United-states , New-jersey

Criticism of puberty blockers misguided, trans girl's mother says

The mother of a transgender teenager says having her child come out at the age of eight let her and her family take a deep collective breath. However, a

Te-whatu , New-zealand-general- , New-zealand , United-kingdom , Britain , Hilary-cass , Health-ministry , Association-for-transgender-healthcare-aotearoa , Health-new-zealand-te-whatu-ora , United-kingdom-national-health-service , National-health-service , Professional-association