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Impact and cost-effectiveness of the 6-month BPaLM regimen for rifampicin-resistant tuberculosis in Moldova: A mathematical modeling analysis

Author summary Why was this study done? Drug resistance poses a major barrier to the effective treatment of tuberculosis, especially in Moldova and other post-Soviet states which have the highest levels of resistance in the world. Individuals with tuberculosis resistant to the key drug rifampicin face a worse prognosis, a longer and more expensive course of treatment, and more side effects than individuals with rifampicin-susceptible tuberculosis. Until recently, the standard of care for rifampicin-resistant tuberculosis (RR-TB) involved many drugs in combination, often given for 18 months or longer. The newer, 6-month “BPaLM” regimen is comprised of 4 drugs (bedaquiline, pretomanid, linezolid, and moxifloxacin) to which resistance levels are currently low, and while it was shown to be just as effective as the standard of care when health outcomes were measured at 72 weeks from treatment initiation, its effect on lifetime health outcomes, costs, and the acquisition of dru ....

United States , United Kingdom , South Africa , Jennifer Thorley , National Institute Of Allergy , Decision Science Methods Group At Erasmus University , Harvard University , Tb Partnership Global Drug Facility , Health Decision Science , Phd Program In Health , Creative Commons Attribution License , National Institute , Infectious Diseases , Global Drug Facility , Consumer Price Index , Moldovan Leu , Gross Domestic Product , Georgian Lei , Soviet Union , Like Moldova , Although South Africa , Phd Program , Health Policy , Decision Science Methods Group , Erasmus University , Drug Therapy ,

Study finds novel weight-loss telewellness program makes financial sense

Study finds novel weight-loss telewellness program makes financial sense
medicalxpress.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medicalxpress.com Daily Mail and Mail on Sunday newspapers.

Desiree Backman , Jeffrey Hoch , Jeffreys Hoch , Neal Kohatsu , Health Education Journal , Uc Davis Health Folsom , Koa Family Program , Telewellness Weight Loss Program , Division Of Health , Uc Davis Center , Department Of Public Health Sciences , Uc Davis Health , Practice Group , Healthcare Policy , Koa Family Study , Health Policy , Public Health Sciences , Family Study , Prevention Policy , Internal Medicine , Cardiovascular Medicine , Cost Effectiveness Analysis , Community Based Telewellness Weight Loss Program ,

Tafenoquine following G6PD screening versus primaquine for the treatment of vivax malaria in Brazil: A cost-effectiveness analysis using a transmission model

Author summary Why was this study done? Radical cure with primaquine or recently approved tafenoquine is required to clear the dormant liver parasites of vivax malaria. While single-dose tafenoquine overcomes the barrier of patient adherence to the current 7-day primaquine treatment, it costs more and requires screening for glucose-6-phosphate dehydrogenase (G6PD) deficiency. While the impact of changing policies to tafenoquine after G6PD screening on transmission has been evaluated, the associated costs and cost-effectiveness will be important considerations for policymakers. What did the researchers find? Using an economic evaluation model coupled with a transmission model, we found that prescribing tafenoquine to vivax malaria patients without G6PD deficiency would be highly likely to be cost-effective in Brazil. Tafenoquine will be particularly cost-effective in settings where patient adherence to the current 7-day treatment is low and when paediatric tafenoquine is available ....

Papua New Guinea , United States , South Korea , Republic Of Korea , Monte Carlo , Jamesg Beeson , Brazilian Unified Health System , National Malaria Control Programme , Ministry Of Health Brazil , Burnet Institute , Technological Development Cnpq , World Health Organisation , Melinda Gates Foundation , National Council For Scientific , National Commission For The Incorporation Of Technologies , Ministry Of Health , National Malaria Prevention , Creative Commons Attribution License , National Council , Technological Development , United States Dollars , South America , While Scenarios , Epidemiological Surveillance Information System , National Commission , Brazilian Unified Health ,

Costs and cost-effectiveness of influenza illness and vaccination in low- and middle-income countries: A systematic review from 2012 to 2022

In a systematic review of economic evaluations, Gharpure and team examine the costs of influenza illness and vaccination programs in low- and middle-income countries to assess potential barriers to global implementation. Full length: In this systematic review of economic evaluations, Radhika Gharpure and colleagues examine the costs of influenza illness, the costs of influenza vaccination programs, and the cost-effectiveness of vaccination from low- and middle-income countries to assess whether gaps remain that could hinder global implementation of influenza vaccination programs. ....

United States , South Africa , Britni Burkhardsmeier , Chris Chadwick , Joanna Taliano , Rakhat Akmatova , Stefano Tempia , Cabrera Escobar , International Monetary Fund , Health Economic Evaluation Reporting Standard , Current Health Expenditure , Strategic Advisory Group Of Experts On Immunization , Government Health Expenditure , Task Force For Global Health , Us Centers For Disease , World Health Organization , World Bank , Us Bureau Of Economic Analysis , Partnership For Influenza Vaccine Introduction , Boston University School Of Public Health , Cochrane Library , Sydney Rosen , Boston University School , Public Health , Creative Commons , Supporting Information ,

Wider access to antivenom in Brazil's Amazon

<p>A study by scientists and physicians from Duke University and two Brazilian institutions evaluated the cost-effectiveness of making snake bite antivenom more available in the Amazonas region. Expanding access to antivenom at both hospitals and community health centers would produce the largest benefits, averting up to 3,922 disability-adjusted life-years (DALYs) while yielding economic benefits of up to US$8.98 million.The findings appear in the January 2024 issue of The Lancet Regional Health - Americas.</p>
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United States , Thiago Rocha , Hui Wen , Charlesj Gerardo , Emilyr Smith , Armand Zimmerman , Heitor Vieira Dourado , Osondu Ogbouji , Ricardo Nickenig Vissoci , Osondu Ogbuoji , Catherine Staton , Joao Ricardo Nickenig Vissoci , Jacqueline Sachett , Wuelton Monteiro , Lancet Regional Health Americas , Butantan Institute , Tropical Medicine Foundation Dr , Duke Global Health Institute , Duke University , Lancet Regional Health , Duke Department Of Emergency Medicine , World Health Organization , Fogarty International Center , Method Of Research , Latin America , Duke Department ,