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1. In this randomized controlled trial, high-dose simvastatin did not reduce the need for organ support among critically ill patients with coronavirus disease 2019 (COVID-19). 2. High-dose simvastatin was associated with increased rates of serious adverse events amongst critically ill patients with COVID-19. Evidence Rating Level: 1 (Excellent) Study Rundown: Among critically ill patients who

1. In this randomized controlled trial, inhaled fluticasone furoate did not shorten the time to recovery for non-hospitalized patients with mild-to-moderate coronavirus disease 2019 (COVID-19) compared to a placebo. 2. Adverse events were not common in the fluticasone furoate or the placebo group. Evidence Rating Level: 1 (Excellent) Study Rundown: As the COVID-19 pandemic continues,

Anxious individuals consistently fail in controlling emotional behavior, leading to excessive avoidance, a trait that prevents learning through exposure. Although the origin of this failure is unclear, one candidate system involves control of emotional actions, coordinated through lateral frontopolar cortex (FPl) via amygdala and sensorimotor connections. Using structural, functional, and neurochemical evidence, we show how FPl-based emotional action control fails in highly-anxious individuals. Their FPl is overexcitable, as indexed by GABA/glutamate ratio at rest, and receives stronger amygda...

The Patient Protection and Affordable Care Act (ACA) Medicaid Expansion was found to decrease suicide rates among younger adults.

Researchers in South Korea and France have conducted an analysis on individuals infected with Omicron variant (B.1.1.529) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to estimate the epidemic potential and long-term prospects of this virus in circulation. They have found that the basic reproduction number (R0) for this variant is 1.90, while the mean serial interval is 2.22 days.