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Simvastatin does not improve outcomes in patients critically ill with COVID-19

1. In this randomized controlled trial, high-dose simvastatin did not reduce the need for organ support among critically ill patients with coronavirus disease 2019 (COVID-19). 2. High-dose simvastatin was associated with increased rates of serious adverse events amongst critically ill patients with COVID-19. Evidence Rating Level: 1 (Excellent) Study Rundown: Among critically ill patients who ....

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No evidence IV vitamin C aids critically ill COVID-19 patients

No evidence IV vitamin C aids critically ill COVID-19 patients
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Francois Lamontagne , University De Sherbrooke , Multifactorial Adaptive Platform Trial For Community , Lessening Organ Dysfunction , Multifactorial Adaptive Platform Trial , Community Acquired Pneumonia ,

Intravenous Vitamin C for Patients Hospitalized With COVID-19

Two randomized clinical trials were harmonized to compare the effect of vitamin C vs control on outcomes in hospitalized patients with COVID-19 who were critica ....

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Managing hospitalized patients with COVID-19 : JAAPA

Managing hospitalized patients with COVID-19 : JAAPA
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Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis | Critical Care Medicine | JAMA

This meta-analysis pools data from 7 randomized trials to estimate the association between administration of corticosteroids vs usual care or placebo and all-ca ....

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