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Research Uncovers Secret to Controlling Cell Molecules

Research Uncovers Secret to Controlling Cell Molecules
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25 Early Career Scientists Become HHMI Hanna Gray Fellows

The Howard Hughes Medical Institute announces the selection of 25 exceptional early career scientists as 2022 Hanna Gray Fellows. The 2023 Hanna H. Gray Fellows Program competition is now open for applications.

California , United-states , Johns-hopkins-university , Maryland , Arizona , Berkeley , University-of-washington , Washington , Stanford-university , Chevy-chase , San-francisco , Harmits-malik

Researchers develop tool to speed up the study of enzymes

Researchers develop tool to speed up the study of enzymes
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New tool dramatically speeds up research into enzymes

New tool dramatically speeds up research into enzymes
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Dan-herschlag , Researchers-at-stanford-university , Stanford-university , High-throughput-microfluidic-enzyme , ஆராய்ச்சியாளர்கள்-இல்-ஸ்டான்போர்ட்-பல்கலைக்கழகம் , ஸ்டான்போர்ட்-பல்கலைக்கழகம் ,

Lab-on-a Chip Expands Functional Studies of Enzyme Variants


Lab-on-a Chip Expands Functional Studies of Enzyme Variants
July 22, 2021
A microfluidic platform for high-throughput expression, purification, and characterization of enzyme variants has been applied to the study of a familiar enzyme, PafA (phosphate-irrepressible alkaline phosphatase of Flavobacterium). [Daniel Mokhtari, Stamford University]
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Just because an enzyme has an active site doesn’t mean the rest of the enzyme should be disregarded, as though it were so much dead weight. It influences enzyme function, if only by keeping the enzyme from unraveling and losing its function altogether. The rest of the enzyme may also fine-tune enzyme function in ways that are rather more subtle too subtle, alas, to be determined without the patient study of enzyme variants, that is, versions of the enzyme that incorporate one or more mutations. Because studying how mutations affect enzyme function is such a painstaking business, the mutations that are assessed tend to be close to you guessed it the active site.

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Stanford researchers develop tool to drastically speed up the study of enzymes

Stanford researchers develop tool to drastically speed up the study of enzymes
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New tool drastically speeds up the study of enzymes

New tool drastically speeds up the study of enzymes
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