Study finds increased risk for cancer overall and for specific cancers for first- and second-degree relatives. Relatives of patients with myelodysplastic neoplasia (MDS), acute myeloid leukemia (AML), or acute lymphoblastic leukemia (ALL) have an increased risk for cancer.
Study shows risk for cancer increases for relatives of patients with leukemia medicalxpress.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medicalxpress.com Daily Mail and Mail on Sunday newspapers.
In this Danish nested case-control study, Nelsan Pourhadi and colleagues investigate the influence of the progestin-component of menopausal hormone therapy on central nervous system tumors.
Objective To describe the long term risk of cervical cancer in women with untreated (that is, undergoing active surveillance) or immediately treated cervical intraepithelial neoplasia grade 2 (CIN2).
Design Nationwide population based historical cohort study.
Setting Danish healthcare registries.
Participants Women with CIN2 diagnosed in 1998-2020 and aged 18-40 years at diagnosis, who had either active surveillance or immediate treatment with large loop excision of the transformation zone (LLETZ). Women with a previous record of CIN2 or worse or LLETZ were excluded.
Main outcome measure A Weibull survival model for interval censored time-to-event data was used to estimate the cumulative risk of cervical cancer. Inverse probability treatment weighting was used to adjust estimates for age, index cytology, calendar year, and region of residence.
Results The cohort included 27 524 women with CIN2, of whom 12 483 (45%) had active surveillance and 15 041 (55%) had immediate LLETZ. During follow-up, 104 cases of cervical cancer were identified 56 (54%) in the active surveillance group and 48 (46%) in the LLETZ group. The cumulative risk of cervical cancer was comparable across the two groups during the active surveillance period of two years. Thereafter, the risk increased in the active surveillance group, reaching 2.65% (95% confidence interval 2.07% to 3.23%) after 20 years, whereas it remained stable in the LLETZ group at 0.76% (0.58% to 0.95%).
Conclusions Undergoing active surveillance for CIN2, thereby leaving the lesion untreated, was associated with increased long term risk of cervical cancer compared with immediate LLETZ. These findings show the importance of continued follow-up of women having active surveillance.
This study was conducted on the remote servers of the Danish Health Data Authority. Owing to Danish legislation, individual level data cannot be shared by the authors, and in cell counts actual numbers less than five cannot be reported. Data can be accessed after application to the Danish Health Data Authority.
Diabetes linked to poorer survival after nephrectomy for renal cell carcinoma healio.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from healio.com Daily Mail and Mail on Sunday newspapers.