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3D in vitro human atherosclerosis model for high-throughput drug screening

3D in vitro human atherosclerosis model for high-throughput drug screening
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United States , University Of Georgia , Emory University , Georgia Institute Of Technology , Patrick Taejoon Hwang , Jun Chen , Wook Jun , Xixi Zhang , Gillian Huskin , Hanjoong Jo , Robbie Cross Jr , Heersink School Of Medicine , School Of Engineering , School Of Medicine , Department Of Medicine Division Endocrinology , Department Of Medicine Division Cardiovascular Disease , Augusta University Of Georgia Medical Partnership , Marnixe Heersink School Of Medicine , Drug Agency Modernization , Department Of Biomedical Engineering , L Harbert Institute For Innovation , National Institutes Of Health , Ho Wook Jun , Biomedical Engineering , United States Food , Drug Agency Modernization Act ,

3D nanomatrix vascular sheet model for high-throughput atherosclerosis drug testing

A groundbreaking 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, University of Alabama at Birmingham researchers report in the journal Biomaterials. ....

Emory University , United States , University Of Georgia , Georgia Institute Of Technology , Hanjoong Jo , Robbie Cross Jr , Wook Jun , Jun Chen , Patrick Taejoon Hwang , Xixi Zhang , Gillian Huskin , University Of Alabama At Birmingham , Department Of Medicine Division Cardiovascular Disease , School Of Medicine , National Institutes Of Health , Drug Agency Modernization , Augusta University Of Georgia Medical Partnership , School Of Engineering , Department Of Biomedical Engineering , L Harbert Institute For Innovation , Department Of Medicine Division Endocrinology , Marnixe Heersink School Of Medicine , Heersink School Of Medicine , Biomedical Engineering , United States Food , Drug Agency Modernization Act ,

3D in vitro human atherosclerosis model for high-throughput drug screening

This advance should facilitate atherosclerosis drug discovery and development. Ho-Wook Jun, Ph.D., Photography: Steve WoodA groundbreaking 3D, three-layer nanomatrix vascular sheet that possesses multiple features of ath. ....

University Of Georgia , United States , Georgia Institute Of Technology , Emory University , Xixi Zhang , Steve Wood , Jun Chen , Robbie Cross Jr , Hanjoong Jo , Wook Jun , Patrick Taejoon Hwang , Gillian Huskin , National Institutes Of Health , School Of Medicine , School Of Engineering , Marnixe Heersink School Of Medicine , Heersink School Of Medicine , Department Of Biomedical Engineering , L Harbert Institute For Innovation , Department Of Medicine Division Endocrinology , Augusta University Of Georgia Medical Partnership , Department Of Medicinedivision Cardiovascular Disease , Drug Agency Modernization , University Of Alabama At Birmingham , Inside Ho Wook , Steve Wooda ,

UAB researchers show beneficial effect of verapamil for patients with Type 1 diabetes

In 2012, University of Alabama at Birmingham researcher Anath Shalev, M.D., reported that a decades-old blood pressure medication called verapamil completely reversed diabetes in animal models. ....

Cornell University , New York , United States , Praveen Sethupathy , Wei Jun Qian , Junqin Chen , Eugenec Gwaltney , Lily Ramsey , Guanlan Xu , Brian Lu , Diabetes Research , National Institutes Of Health , Department Of Medicine , Marnixe Heersink School Of Medicine , University Of Alabama At Birmingham , National Institute Of Diabetes , Division Of Endocrinology , Diabetes Research Center Pilot , Diabetes Center , Department Of Medicine Division Endocrinology , Pacific Northwest National Laboratory , Anath Shalev , Medicine Division , National Institutes , Research Center Pilot , National Institute ,

In Type 1 diabetes, verapamil prevents decline of IGF-1 and promotes beta-cell IGF-1 signaling

These results add an additional, mechanistic aspect to further explain how the decades-old blood pressure medication verapamil can preserve beta cell function in Type 1 diabetes patients by affecting the hormone insulin-. ....

Cornell University , New York , United States , Brian Lu , Junqin Chen , Praveen Sethupathy , Guanlan Xu , Eugenec Gwaltney , Wei Jun Qian , National Institutes Of Health , Division Of Endocrinology , Department Of Medicinedivision Endocrinology , Diabetes Center , Department Of Medicine , Pacific Northwest National Laboratory , Marnixe Heersink School Of Medicine , National Institute Of Diabetes , Department Of Medicine Division Endocrinology , Diabetes Research , Diabetes Research Center Pilot , University Of Alabama At Birmingham , Stream Diabetes , Anath Shalev , Medicine Division , National Institutes , Research Center Pilot ,