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Discovery pinpoints new therapeutic target for atopic dermatitis

Credit: Dave Cullen
Researchers from Trinity College Dublin have discovered a key mechanism underlying bacterial skin colonisation in atopic dermatitis, which affects millions around the globe.
Atopic dermatitis (AD, also called commonly eczema) is the most common chronic inflammatory skin disorder in children, affecting 15-20% of people in childhood. During disease flares, patients experience painful inflamed skin lesions accompanied by intense itch and recurrent skin infection.
The bacterium Staphylococcus aureus (S. aureus) thrives on skin affected by AD, increasing inflammation and worsening AD symptoms. Although a small number of therapies are available at present for patients with moderate to severe AD, it is vital that we understand how S. aureus colonises AD skin so that we can develop new treatments that directly target the bacterium. ....

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Human migration patterns connected to vitamin D deficiencies today

A new study in the
Oxford Economic Papers finds that migration flows the last 500 years from high sunlight regions to low sunlight regions influence contemporary health outcomes in destination countries.
The researchers here noted that people s ability to synthesize vitamin D from sunlight declines with skin pigmentation, and that vitamin D deficiency is directly associated with higher risk of mortality, from illnesses including cardiovascular disease, type 1 and type 2 diabetes, hypertension, and certain cancers. Recent research even .finds that vitamin D affects the severity of COVID-19.
Researchers here focused on groups from high sunlight regions that migrated to low sunlight regions between 1500 and today. The resulting population shifts caused the risk of vitamin D deficiency to rise substantially. The researchers explored the aggregate health consequences of such migration over a long historical perspective. ....

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WHY IS MY PET SO ITCHY??

We often think of allergies as pollen that causes us to sneeze, cough and make our eyes water. Did you know your pet can have allergies too? However, allergies in ....

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