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Researchers from the Spanish National Cancer Research Centre (CNIO) and the IDIBELL, led by Eva González-Suárez at the CNIO, have found that the hyperactivation of the RANK pathway plays a double function in breast cells: in the early stages of cancer, it activates senescence, which has a protective effect and delays the appearance of tumours; in more advanced stages, RANK-induced senescence favours the accumulation of stem cells, which promotes tumour growth and aggressiveness.

A gene called  GAS2 plays a key role in normal hearing, and its absence causes severe hearing loss, according to a study led by researchers in the Perelman School of Medicine at the University of Pennsylvania. Developmental Cell, discovered that the protein encoded by  GAS2 is crucial for maintaining the structural stiffness of support cells in the inner ear that normally help amplify incoming sound waves. They showed that inner ear support cells lacking functional  GAS2 lose their amplifier abilities, causing severe hearing impairment in mice. The researchers also identified people who...

Discovery of a new genetic cause of hearing loss illuminates how inner ear works A Penn Medicine study shows a link between mutations of the GAS2 gene and the ability to amplify incoming sound, providing a research target for future gene therapy. A gene called  GAS2 plays a key role in normal hearing, and its absence causes severe hearing loss, according to a study led by researchers in Penn’s Perelman School of Medicine. Developmental Cell, discovered that the protein encoded by  GAS2 is crucial for maintaining the structural stiffness of support cells in the ...

 E-Mail IMAGE: Lipid kinases produce an active messenger that coordinates communications between peroxisomes and mitochondria--two organelles intimately involved in making and using fuel to support cellular growth. view more  Credit: CI Photos LA JOLLA, CALIF. - May 12, 2021 - Scientists at Sanford Burnham Prebys Medical Discovery Institute have taken a deep dive into a previously overlooked family of proteins and discovered that they are essential to maintaining the energy that cells need to grow and survive. The proteins, known as lipid kinases, produce messengers that help balanc...

A gene called GAS2 plays a key role in normal hearing, and its absence causes severe hearing loss, according to a study led by researchers in the Perelman School of Medicine at the University of Pennsylvania.