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Twenty years ago, a drug candidate was rejected due to its side effects. Researchers have now figured out how to potentially make a successor molecule more selective.
Formaldehyde can inhibit enzymes that produce hydrogen particularly efficiently. Researchers from Bochum have discovered how this can be prevented. Enzymes from microorganisms can produce hydroge ...
In nature, enzymes termed hydrogenases are capable of producing molecular hydrogen (H2). Special types of these biocatalysts, so-called [FeFe]-hydrogenases, are extremely efficient and therefore o ...
E-Mail An international research team from the Photobiotechnology Research Group at Ruhr-Universität Bochum (RUB) led by Professor Thomas Happe and the Laboratoire de Bioénergétique et Ingénierie des Protéines (CNRS) in Marseille has been able to get to the bottom of this unique feature. They describe the molecular mechanism in Nature Communications on 2 February 2021. Enzyme repeatedly survives the attack unharmed Representatives of the [FeFe]-hydrogenase enzyme group combine protons and electrons to form molecular hydrogen at particularly high turnover rates. Some of them even use s...