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Frontiers | Tilapia Lake Virus-Induced Neuroinflammation in Zebrafish: Microglia Activation and Sickness Behavior

In mammals, the relationship between the immune system and behavior is widely studied. In fish, however, the knowledge concerning the brain immune response and behavioral changes during brain viral infection is very limited. To further investigate this subject, we used the model of tilapia lake virus (TiLV) infection of zebrafish (Danio rerio), which was previously developed in our laboratory. We demonstrated that TiLV persists in the brain of adult zebrafish for at least 90 days, even when the virus is not detectable in other peripheral organs. The virions were found in the whole brain. During TiLV infection, zebrafish displayed a clear sickness behavior: decreased locomotor activity, reduced food intake, and primarily localizes near the bottom zone of aquaria. Moreover, during swimming individual fish exhibited also unusual spiral movement patterns. Gene expression study revealed that TiLV induces in the brain of adult fish strong anti-viral and inflammatory response and up-regulates ....

United States , Baden Wüberg , Noord Brabant , Novoab Nodavirus , Albert Willemsen Noldus , Oreochromis Niloticus , Oncorhynchus Mykiss , Le Clerc , Clin Microbiol , Pons Garcia , Carassius Auratus , Calcarifer Bloch , Gen Virol , Weissella Cibaria , Kembou Tsofack , Carlos Kreutz , Gray Oreochromis Niloticus , Anim Health Res Rev , Microglia In Development , Jagiellonian University In Krakow , Priority Research Area Bio , Kinga Sawa Jagiellonian University , Zebrafish Models For Translational Neuroscience Research , Research University , Ethics Committee In Krak , Excellence Initiative ,

Women Empowerment Takes Lead in Saudi Kingdom: KSA Celebrates its First Women Beauty and Wellness 2020 Award


The Kingdom of Saudi Arabia has celebrated its first Beauty and Wellness Awards 2020.
This innovative ceremony has been hosted as a virtual event due to the current COVID restrictions in the country. The aim of the awards was to appreciate and highlight the exclusive role of Saudi women for their immense contribution in gender empowerment.
Sara Rayees – Modest Fashion Designer of the year
The nominated winners had been announced through an online event on March 8th on International Women’s Day.
“We are honored to be a part of this unique event recognizing the amazing successes of inspirational women of Saudi Arabia. The empowerment of women and girls is very important for a developed nation and we are proud to support this initiative.“ said Khalid Aldarwish, CEO and founder of Manuel Market. ....

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