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New model predicts individual myeloma risk and treatment response

A multicenter collaboration led by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine has produced the first computational model for newly diagnosed multiple myeloma that predicts an individual's personalized prognosis based on their tumor genomics and treatments. ....

United States , C Ola Landgren , Francesco Maura , Sylvester Myeloma Institute , Heidelberg University Hospital , Division Of Myeloma , Sylvester Comprehensive Cancer Center , Moffitt Cancer Center , Langone Health , University Of Miami Miller School Medicine , Memorial Sloan Kettering Cancer Center , Miami Miller School , Sylvester Myeloma , Multiple Myeloma ,

New algorithm proves to be a powerful tool for detection and identification of novel bacterial organisms

Researchers developed the NOVA algorithm to systematically analyze bacterial isolates unidentified using traditional methods such as matrix-assisted laser desorption ionization-time of flight mass spectrometry and partial 16S rRNA gene sequencing using whole genome sequencing. ....

Kateryna Kon Shutterstock , Bruker Daltonics , University Hospital Basel , National Center , Novel Organism Verification , Biotechnology Information , Prokaryotic Names , Gene Sequencing , Maldi Tof , Mass Spectrometry , Ibonucleic Acid , Whole Genome Sequencing ,

Scientists unveil the hidden respiratory mechanisms of gut bacteria

Study explores the use of respiratory electron acceptors by diverse gut bacteria, revealing a novel type of anaerobic respiration linked to the gut metabolome and microbial energy metabolism. ....

Kateryna Kon Shutterstock , Nature Microbiology , Kateryna Kon , Adenosine Triphosphate , Amino Acid ,

Largest genetic study of gestational diabetes discovers nine novel genetic regions linked to severe and common pregnancy complication

Researchers investigated the genetic underpinnings of Gestational Diabetes Mellitus (GDM) and its relationship with Type 2 Diabetes (T2D) through a genome-wide association study ((GWAS), identifying distinct and shared genetic factors. ....

Photoroyalty Shutterstock , Coloc Association Visualization , Nature Genetics , Gestational Diabetes Mellitus , Finnish Biobank , Biobank Access Decisions , Ridge Regression Based Efficient , Single Effects , Single Nucleotide Polymorphisms , Estonian Biobank , Ensembl Variant Effect Predictor , Finnish European , Integration Resource , Expression Quantitative Trait Loci , Multi Marker Analysis , Genomic Annotation , Linkage Disequilibrium Score Regression , Tabula Muris , Significant Cross Trait Outliers , Joint York , Gestational Diabetes , Diabetes Mellitus , Type 2 Diabetes ,

Discovery on housekeeping genetic elements reveals a novel avenue in cancer therapy

Technological advancements have enabled scientists to comprehensively explore genetic control elements, unraveling the complexities of gene activation mechanisms in our genetic code. ....

Kenta Nakai , Martin Loza , Alexis Vandenbon , Laboratory Of Functional Analysis , Nucleic Acids Research On , Kyoto University , University Of Tokyo , Institute Of Life , Institute Of Medical Science , Medical Science , Functional Analysis , Professor Kenta Nakai , Assistant Professor , Associate Professor , Medical Sciences , Nucleic Acids Research , Cancer Therapy , Cancer Treatment , Hromosome 19 , Ucleic Acid ,