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[inaudible conversations] good morning. The committee will come to order. Id like to welcome you all to our second bubble confirmation hearing of this anon girls feet. I would like to start by thanking senator korn and for being here to speak on behalf of our nominee is. Always good to have you. Our fellow committee member, senator mention from West Virginia is prepared to also offer introductory remarks for a nominee. Governor perry, i would like to extend a warm welcome to you and to your family. Know that i appreciate your desire to serve, your willingness to become our next secretary of en...

A critical challenge for microbiology and medicine is how to cure infections by bacteria that survive antibiotic treatment by persistence or tolerance. Seeking mechanisms behind such high survival, we developed a forward-genetic method for efficient isolation of high-survival mutants in any culturable bacterial species. We found that perturbation of an essential biosynthetic pathway (arginine biosynthesis) in a mycobacterium generated three distinct forms of resistance to diverse antibiotics, each mediated by induction of WhiB7: high persistence and tolerance to kanamycin, high survival upon e...