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Study identifies major flaws in iBMEC-based models of the blood-brain barrier A type of cell derived from human stem cells that has been widely used for brain research and drug development may have been leading researchers astray for years, according to a study from scientists at Weill Cornell Medicine and Columbia University Irving Medical Center. The cell, known as an induced Brain Microvascular Endothelial Cell (iBMEC), was first described by other researchers in 2012, and has been used to model the special lining of capillaries in the brain that is called the "blood-brain barrier." Many b...

Dublin, Feb. 08, 2021 (GLOBE NEWSWIRE) -- The "Global Genomic Data Analysis and Interpretation Market: Focus on Products, Genomic Platforms,...

Elevated ACE2 and inflammation levels increase risk for pregnant women infected with SARS-CoV-2 Among the hundred million or so cases of coronavirus disease 2019 (COVID-19) that have occurred since the pandemic began, pregnant women have been a conspicuous risk group. However, the exact nature of the risk they and their fetuses face, and the mechanism by which it operates, is far from clear. A new preprint research paper posted to the medRxiv* server throws some light on this area by revealing the presence of significant inflammation at the maternal-fetal interface. Study: SARS-CoV-2 infecti...

Scientists study how different genes dance to the circadian rhythm In 2017, the Nobel Prize in Physiology or Medicine went to three scientists who uncovered the molecular mechanisms that control the circadian rhythm, otherwise known as the "wake-sleep" cycle. To carry out their work, the scientists used the common fruit fly Drosophila melanogaster, making this the sixth Nobel to be awarded to research involving it. Fruitful fruit flies Life scientists have been using Drosophila for over a century now. First proposed by entomologist Charles W. Woodworth as a model organism, its use in resear...

Novel method for identifying biomarkers may aid in early cancer diagnosis A new University of California, Irvine-led study finds a new method for identifying biomarkers may aid in early cancer diagnosis. The study focused on lung cancer, however the Cell Heterogeneity-Adjusted cLonal Methylation (CHALM) method has been tested on aging and Alzheimer's diseases as well and is expected to be effective for studying other diseases. We found the CHALM method may be a valuable tool in helping researchers to identify more reliable differentially methylated genes from sequence-based methylation data. ...