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Researchers identify human BCAS3 and C16orf70 as novel autophagic proteins

Researchers identify human BCAS3 and C16orf70 as novel autophagic proteins
Autophagy is an intracellular degradation process of cytosolic materials and damaged organelles. Researchers at Ubiquitin Project of TMIMS have been studying the molecular mechanism of mitophagy, the selective autophagy process to eliminate damaged mitochondria. PINK1 (a serine/threonine kinase) and Parkin (a ubiquitin ligating enzyme: E3) work together to ubiquitylate the outer membrane proteins of damaged mitochondria, then ubiquitin chains are recognized as signals for autophagy degradation. Dysfunction of mitophagy causes a decrease in mitochondrial quality with overproduction of ROS, and is linked to neurodegenerative diseases like Parkinson s disease. ....

Emily Henderson , Ubiquitin Project , Breast Carcinoma Amplified Sequence , Drug Discovery , Life Science , Neurodegenerative Diseases , Parkinson 39s Disease , எமிலி ஹென்டர்சன் , மார்பக புற்றுநோய் பெருக்கப்பட்டது வரிசை , மருந்து கண்டுபிடிப்பு , வாழ்க்கை அறிவியல் ,

Researchers decipher how interspecies interactions arise, evolve and are maintained

Researchers decipher how interspecies interactions arise, evolve and are maintained
Interspecies interactions are the foundation of ecosystems, from soil to ocean to the human gut. Among the many different types of interactions, syntrophy is a particularly important and mutually beneficial interspecies interaction where one partner provides a chemical or nutrient that is consumed by the other in exchange for a reward.
Syntrophy plays an essential role in global carbon cycles by mediating the conversion of organic matter to methane, which is about 30 times more potent than carbon dioxide as a greenhouse gas and is a source of sustainable energy. And in the human gut, trillions of microbial cells also interact with each other and other species to modulate the physiology of their human host. ....

Nitin Baliga , Serdar Turkarslan , Emily Henderson , Baliga Lab , Study Co , Institute For Systems Biology , Study Co Corresponding Author , Senior Vice President , நிடின் பலிகா , எமிலி ஹென்டர்சன் , பலிகா ஆய்வகம் , படிப்பு இணை , நிறுவனம் க்கு அமைப்புகள் உயிரியல் , மூத்தவர் துணை ப்ரெஸிடெஂட் ,

New mRNA treatment appears to stop replication of flu and Covid-19 viruses

With a relatively minor genetic change, a new treatment developed by researchers at the Georgia Institute of Technology and Emory University appears to stop replication of both flu viruses and the virus that causes Covid-19. ....

Daryll Vanover , Chiara Zurla , Philip Santangelo , Emily Henderson , Centers For Disease , Kennesaw State University , Wallaceh Coulter Department Of Biomedical Engineering , Emory University , Georgia Institute Of Technology , Georgia State University , University Of Georgia , Georgia Institute , Disease Control , Defense Advanced Research Projects Agency , Protective Alleles , Response Elements , Sars Cov 2 , பிலிப் சந்தங்கேளோ , எமிலி ஹென்டர்சன் , மையங்கள் க்கு நோய் , கென்னேசவ் நிலை பல்கலைக்கழகம் , உணர்ச்சி பல்கலைக்கழகம் , ஜார்ஜியா நிறுவனம் ஆஃப் தொழில்நுட்பம் , ஜார்ஜியா நிலை பல்கலைக்கழகம் , பல்கலைக்கழகம் ஆஃப் ஜார்ஜியா , ஜார்ஜியா நிறுவனம் ,

Researchers identify new molecular mechanisms in chronic skin inflammation

Researchers identify new molecular mechanisms in chronic skin inflammation
Frequently occurring chronic skin inflammation like in atopic dermatitis (AD or neurodermatitis) and psoriasis have different causes such as genetic predisposition, stress or allergens.
These frequently occurring skin diseases are mostly attributed by biomedical scientists to a disturbed immune system, although the noticeable thickening and flaking of the epidermis, which is the outermost layer of skin, also indicates a disruption of the epithelial cells.
A team of researchers from the University Clinic for Dermatology and the Clinical Institute for Laboratory Medicine at MedUni Vienna has now been able to identify new molecular mechanisms as causes that could provide suitable starting points for new therapies. ....

Erwin Wagner , Emily Henderson , University Clinic For Dermatology , University Clinic , Clinical Institute , Laboratory Medicine , Meduni Vienna , Atopic Dermatitis , Immune System , அர்‌விந் வாக்னர் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் சிகிச்சையகம் க்கு தோல் நோய் , பல்கலைக்கழகம் சிகிச்சையகம் , மருத்துவ நிறுவனம் , ஆய்வகம் மருந்து , தோல் நோய் , நோய் எதிர்ப்பு சக்தி அமைப்பு , மன அழுத்தம் ,

Genetic variation associated with COVID-19 outcome

Genetic variation associated with COVID-19 outcome
The severity of outcome from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is widely varied, with most individuals remaining asymptomatic while others experience severe life-threatening pneumonia and multi-organ failure. Host genetics play a role in disease progression and prognosis. A paper recently uploaded to the preprint server
et al. (1
st March 2021) identifies several alleles associated with the gene natriuretic peptide receptor C (NPR3) that may impact disease severity.
How was the study performed?
The group worked with 4,488 high-risk COVID-19 outpatients being over 40 years of age and having at least one other comorbidity such as diabetes or obesity. The group was split into two equal sizes, one of which received a placebo, while the other received 0.5 mg colchicine, an anti-inflammatory, daily for a month. The patients were evaluated for disease symptoms 15 and 30 days into ....

Michael Greenwood , Image Credit , Chromosome 9 , Corona Virus , Coronavirus Disease Covid 19 , Sars Cov 2 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , மைக்கேல் கிரீன்வுட் , படம் கடன் , கொரோனா வைரஸ் , நீரிழிவு நோய் , உடல் பருமன் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,