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Evonik partners with BioNTech to manufacture lipids for COVID-19 vaccine


Evonik partners with BioNTech to manufacture lipids for COVID-19 vaccine
Caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the coronavirus disease 2019 (COVID-19) pandemic continues to spread across the globe. The rise to dominance of several new variants of concern, some with observed heightened transmissibility, has contributed to a resurgence in cases in many parts of the world – particularly in the U.S., the U.K., Brazil, and South Africa. To date, over 107 million cases of COVID-19 have been confirmed worldwide, with over 2.35 million deaths.
Since the virus was first detected in Wuhan, China, in December 2019, the global scientific community has been mounting an unprecedented research effort to better understand SARS-CoV-2 – from its transmission dynamics, to its complex mechanisms of infection, to its pathogenicity. ....

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Study discovers similarities between the genetic bases of various eating disorders


Study discovers similarities between the genetic bases of various eating disorders
Anorexia nervosa, bulimia nervosa and binge-eating disorder are the three main eating disorders that 4 out of in 10 individuals living in Western Europe will experience at some point in their lives.  In recent years, studies on the genetic basis of anorexia nervosa have highlighted the existence of predisposing genetic markers, which are shared with other psychiatric disorders.
By analyzing the genome of tens of thousands of British people, a team from the University of Geneva (UNIGE), the University Hospitals of Geneva (HUG), King s College London, the University College London, the University of North Carolina (UNC) and The Icahn School of Medicine at Mount Sinai have built on these initial results by discovering similarities between the genetic bases of these various eating disorders, and those of other psychiatric disorders. ....

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Deep learning-based splice-AI can help predict the onset of Alzheimer's disease


Deep learning-based splice-AI can help predict the onset of Alzheimer s disease
Korea Brain Research Institute (KBRI, President Suh Pann-ghill) announced that the research team led by Dr. Jae-Yeol Joo discovered new cryptic splice variants and SNVs in PLCg1 gene of AD-specific models for the first time using Splice-AI.
This research outcome was published in
PNAS, a world-renowned academic journal.
Prediction of Alzheimer s Disease-Specific phospholipase c gamma-1 SNV by Deep Learning-Based Approach for High-Throughput Screening
Alternative splicing variant regulates gene expression and influences diverse phenotypes. Especially, genetic variants arising due to RNA splicing are frequently found in individuals having neurodevelopmental disorders. ....

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Diverse patient population helps identify gene variant associated with childhood asthma


Diverse patient population helps identify gene variant associated with childhood asthma
Researchers at Henry Ford Health System, as part of a national asthma collaborative, have identified a gene variant associated with childhood asthma that underscores the importance of including diverse patient populations in research studies.
The study is published in the print version of the
American Journal of Respiratory and Critical Care Medicine.
For 14 years researchers have known that a casual variant for early onset asthma resides on chromosome 17, which holds one of the most highly replicated and significant genetic associations with asthma. Henry Ford researchers acknowledged they would not have identified it in this study without a diverse patient population that included African Americans, many from the metro Detroit area. ....

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