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Now, a new study, posted to the bioRxiv preprint server by the same researchers, focussing on the Austrian region, found that SARS-CoV-2 transmission bottlenecks to be much tighter than previously thought. ....
Study explores individual differences of SARS-CoV-2 infection in ACE2-expressing stem cells The clinical phenotype of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is remarkable for its wide range of severity among individual patients. Genetic variations are known to mediate part of these differences. To examine these differences, researchers in a new study used human induced pluripotent stem cells (iPSCs) from different genetically diverse individuals. These cells are used to model genetic disease since they contain the donor’s genetic information. The study, published as a preprint on the bioRxiv server, uses a panel of iPSCs from over 500 individuals. The researchers preferred undifferentiated iPSCs to reduce the time required to differentiate them, especially since infection is not always reliable. ....
Early diagnosis of Alzheimer's disease has been shown to reduce cost and improve patient outcomes, but current diagnostic approaches can be invasive and costly. ....
A biologist studying the genetic code is interested to know the number of possible arrangements of 12 molecules in a chain. The chain contains 4 . ....
UK and South African SARS-CoV-2 variants show higher binding affinity to host cell receptor Public health officials are concerned over new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants emerging in various parts of the world. The B.1.1.7 variant was first found in the United Kingdom and found to have the N501Y mutation that allows it to have a faster transmission rate than previous strains. The B.1.351 variant was detected in South Africa and also has the N501Y genetic mutation observed in B.1.1.7. However, scientists are also concerned over two other genetic mutations K417N and E484K that have shown an ability to evade the immune system. Prior evidence has found the B.1.351 variant resistant to neutralizing antibodies produced from either prior infection or vaccination. ....