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Study: Interbacterial toxins may contribute to bacterial genetic diversity

Study: Interbacterial toxins may contribute to bacterial genetic diversity
A toxin produced by bacteria as a defense mechanism causes mutations in target bacteria that could help them survive, according to a study published today in
eLife.
The finding suggests that competitive encounters between bacterial cells could have profound consequences on the evolution of bacterial populations.
When bacterial cells come into contact, they often produce toxins as a defense mechanism. Although it is known that the bacteria producing these toxins have a competitive advantage, exactly how the toxins affect the recipient cells is less clear.
Undergoing intoxication is not always detrimental for cells - there are scenarios in which encountering a toxin could provide a benefit, such as generating antibiotic resistance. We wanted to study the effects of a toxin that alters DNA beyond that of cell death and see how it impacts the surviving recipient cells it targets. ....

Joseph Mougous , Emily Henderson , University Of Washington , University Of Washington School Medicine , Howard Hughes Medical Institute Investigator , Study Lead Author , Postdoctoral Scholar , Washington School , Ddda Producing Burkholderia , Howard Hughes Medical Institute , Antibiotic Resistance , Cell Death , E Coli , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் வாஷிங்டன் , பல்கலைக்கழகம் ஆஃப் வாஷிங்டன் பள்ளி மருந்து , ஹோவர்ட் ஹக்ஸ் மருத்துவ நிறுவனம் புலனாய்வாளர் , படிப்பு வழி நடத்து நூலாசிரியர் , போஸ்ட்‌டாக்டொரல் அறிஞர் , வாஷிங்டன் பள்ளி , ஹோவர்ட் ஹக்ஸ் மருத்துவ நிறுவனம் , நுண்ணுயிர்க்கொல்லி எதிர்ப்பு , செல் இறப்பு , ஏ கோலி ,

Adults with Down syndrome more likely to die from COVID-19 than general population

Adults with Down syndrome more likely to die from COVID-19 than general population
A new study by an international team of researchers found that adults with Down syndrome are more likely to die from COVID-19 than the general population, supporting the need to prioritize vaccinating people with the genetic disorder.
Investigators found that adults with Down syndrome were roughly three times more likely to die from COVID-19 than the general population. This increased risk was especially apparent in from fifth decade of life: A 40-year-old with Down syndrome had a similar risk of dying from COVID-19 as someone 30 years older in the general population. ....

United States , United Kingdom , City Of , Comunidad Autonoma De Cataluna , Andre Strydom , Anke Huels , Stephanie Sherman , Alberto Costa , Mara Dierssen , Emily Henderson , King College London , Jerome Lejeune Foundation , Emory University , Barcelona Institute Of Science , Clinical Research Committee , Research Society , National Down Syndrome Society , Emory University Rollins School Of Public Health , National Task Group On Intellectual Disabilities , Case Western Reserve University School Of Medicine , Alana United States Foundation , Angels Foundation , Matthews Foundation , Case Western Reserve University , Infectious Diseases Society Of America , Down Syndrome Medical Interest Group ,

Could rotavirus vaccine platforms aid in the immunization campaign against SARS-CoV-2?

Could rotavirus vaccine platforms aid in the immunization campaign against SARS-CoV-2?
Rotavirus is a common diarrheal disease that affects young children. Live oral rotavirus vaccines have been used to reduce its incidence in many countries. However, with the onset of the coronavirus disease 2019 (COVID-19) pandemic, and amid focus on vaccines as the only definitive method of durable control, a new study describes the possibility of producing a combined vaccine against both infections.
The study began with the generation of recombinant (r)SA11 rotaviruses, into which segment 7 modified RNAs were introduced. These encoded sequences for the non-structural protein NSP3 and some parts of the viral spike. ....

Liji Thomas , Indiana University , Expression Platform , Image Credit , Coronavirus Disease Covid 19 , Sars Cov 2 , Corona Virus , Spike Protein , Structural Protein , இந்தியானா பல்கலைக்கழகம் , வெளிப்பாடு நடைமேடை , படம் கடன் , கொரோனா வைரஸ் , சர்வதேச பரவல் , ஸ்பைக் ப்ரோடீந் , கட்டமைப்பு ப்ரோடீந் ,

Study findings help explain the diversity of cancers in different Li-Fraumeni patients

The most frequently mutated gene in human cancers is called p53. Patients with Li-Fraumeni syndrome, which is a rare disorder that increases the risk of developing several types of cancer, often have an increased risk to develop cancers at early ages if they inherit p53 mutations. ....

Changs Chan , Life Science Alliance , Rutgers Robert Wood Johnson Medical School , Rutgers Cancer Institute Of New Jersey , Rutgers Cancer Institute , New Jersey , Life Science , Li Fraumeni Syndrome , Medical School , மாற்றங்கள் சான் , வாழ்க்கை அறிவியல் கூட்டணி , ரட்ஜர்ஸ் ராபர்ட் மரம் ஜான்சன் மருத்துவ பள்ளி , ரட்ஜர்ஸ் புற்றுநோய் நிறுவனம் ஆஃப் புதியது ஜெர்சி , ரட்ஜர்ஸ் புற்றுநோய் நிறுவனம் , புதியது ஜெர்சி , வாழ்க்கை அறிவியல் , மருத்துவ பள்ளி ,

DNA origami used to analyze the ultra-fast movements of CRISPR enzymes

DNA origami used to analyze the ultra-fast movements of CRISPR enzymes
The remarkable genetic scissors called CRISPR/Cas9, the discovery that won the 2020 Nobel Prize in Chemistry, sometimes cut in places that they are not designed to target. Though CRISPR has completely changed the pace of basic research by allowing scientists to quickly edit genetic sequences, it works so fast that it is hard for scientists to see what sometimes goes wrong and figure out how to improve it.
Julene Madariaga Marcos, a Humboldt postdoctoral fellow, and colleagues in the lab of Professor Ralf Seidel at Leipzig University in Germany, found a way to analyze the ultra-fast movements of CRISPR enzymes, which will help researchers understand how they recognize their target sequences in hopes of improving the specificity. Madariaga Marcos will present the research on Tuesday, February 23 at the 65th Annual Meeting of the Biophysical Society. ....

Julene Madariaga Marcos , Madariaga Marcos , Emily Henderson , Meeting Of The Biophysical Society , Professor Ralf Seidel At Leipzig University , Professor Ralf Seidel , Leipzig University , Annual Meeting , Postdoctoral Fellow , ஜூலீன் மெடேரியாகா மார்கோஸ் , மெடேரியாகா மார்கோஸ் , எமிலி ஹென்டர்சன் , சந்தித்தல் ஆஃப் தி உயிர் இயற்பியல் சமூகம் , ப்ரொஃபெஸர் ரால்ஃப் சீடல் இல் லெயிஸீக் பல்கலைக்கழகம் , ப்ரொஃபெஸர் ரால்ஃப் சீடல் , லெயிஸீக் பல்கலைக்கழகம் , ஆண்டு சந்தித்தல் , போஸ்ட்‌டாக்டொரல் சக ,