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Scientists describe genetic mechanisms behind mating process of ciliates

Scientists describe genetic mechanisms behind mating process of ciliates
Conjugation (or mating) of ciliates is a unique phenomenon among living beings. They have sex not for reproduction or pleasure they seek to increase genetic variation. Scientists from St Petersburg University, together with colleagues from Poland and France, have studied the mating process in five sibling species of the Paramecium aurelia complex. Their findings enabled them to describe genetic mechanisms behind this phenomenon. The research results have been published in the prestigious scientific journal Genome Biology and Evolution.
The mating process is one of the most important mechanisms for maintaining genetic variation in natural populations. The emergence of sexual reproduction turned out to be the most important evolutionary innovation that facilitated the evolution of eukaryotes. Paramecium is a well-known genus of ciliated protists with a complex system of sexes , or mating types. Param ....

Sankt Peterburg , Alexey Potekhin , Emily Henderson , St Petersburg University , Department Of Microbiology , Genome Biology , எமிலி ஹென்டர்சன் , ஸ்டம்ப் பீட்டர்ஸ்பர்க் பல்கலைக்கழகம் , துறை ஆஃப் நுண்ணுயிரியல் , மரபணு உயிரியல் ,

Researchers use functional test to measure the effect of inherited variants in BRCA2 cancer gene

Researchers at Mayo Clinic have combined results from a functional test measuring the effect of inherited variants in the BRCA2 breast and ovarian cancer gene with clinical information from women who received genetic testing to determine the clinical importance of many BRCA2 variants of uncertain significance (VUS). ....

United States , Emily Henderson , National Institutes For Health , American College Of Medical Genetics , Mayo Clinic , American Journal , National Institutes , Clinical Variant Database , Fergus Couch , American College , Medical Genetics , Breast Cancer , Brca2 Gene , Ovarian Cancer , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , தேசிய நிறுவனங்கள் க்கு ஆரோக்கியம் , அமெரிக்கன் கல்லூரி ஆஃப் மருத்துவ ஜெநெடிக்ஸ் , மயோ சிகிச்சையகம் , அமெரிக்கன் இதழ் , தேசிய நிறுவனங்கள் , மருத்துவ மாறுபாடு தரவுத்தளம் , ஃபெர்கஸ் படுக்கை , அமெரிக்கன் கல்லூரி , மருத்துவ ஜெநெடிக்ஸ் , மார்பக புற்றுநோய் ,

New study reveals genetic influence on cancer immune responsiveness

New study reveals genetic influence on cancer immune responsiveness
20 Feb 2021 - 10:28
The Peninsula
Doha: Sidra Medicine and Qatar Computing Research Institute (QCRI) at Hamad Bin Khalifa University (HBKU), Qatar Foundation, led a research study with the University of California San Francisco (UCSF) that represents a significant step toward personalised cancer immunotherapeutic approaches.
The international team of cancer immunologists, computational scientists, oncologists, biologists, and geneticists found that pre-existing anti-cancer immunity depends heavily on a patient’s genetic background. As such, certain genetic variants that make each of us unique can also influence the way the immune system fights tumors.
Immunotherapy, a therapeutic approach based on boosting the immune system, has changed the way cancer is treated, yet only a minority of patients respond to the treatment. ....

Ad Daw Ah , Younes Mokrab , Wouter Hendrickx Jessica Roelands , Rosalyn Sayaman , Elad Ziv , Mohamad Saad , Najeeb Syed , Davide Bedognetti , Qatar Computing Research Institute , Hamad Bin Khalifa University , Qatar Foundation , College Of Health , Cancer Research Department At Sidra Medicine , Life Sciences , University Of California San Francisco , Sidra Medicine , California San Francisco , Cancer Research Department , Adjunct Associate Professor , Qatar National Research Fund , National Priorities Research Program , எலத் ஜிவ் , மஹாமட் ஸாட் , நஜீப் சையத் , கத்தார் கணினி ஆராய்ச்சி நிறுவனம் , ஹமாத் பின் கலீஃப பல்கலைக்கழகம் ,

Transforming immune killer T-cells into 'super soldiers' to fight against cancer

Transforming immune killer T-cells into super soldiers to fight against cancer
Creating super soldiers of specific white blood cells to boost an anti-tumor response has been shown in a series of elegant experiments by Princess Margaret researchers.
Research led by Ph.D. candidate Helen Loo Yau, Post-doctoral fellow Dr. Emma Bell and Senior Scientist Dr. Daniel D. De Carvalho describes a DNA modifying epigenetic therapy that can transform immune killer T-cells into super soldiers by boosting their ability to kill cancer cells.
Their findings could potentially enhance immunotherapy, a new paradigm in cancer treatment currently effective for a minority of cancer patients. Some patients respond well to immunotherapy, with their tumours drastically shrinking in size, but others respond only partially or not at all. Clinicians and scientists around the world are working to understand why immunotherapy only helps some patients. ....

Emma Bell , Emily Henderson , University Of Toronto , Department Of Medical Biophysics , Princess Margaret , Helen Loo Yau , Senior Scientist , Molecular Cell , Associate Professor , Medical Biophysics , Cancer Treatment , T Cell , எம்மா மணி , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் டொராண்டோ , துறை ஆஃப் மருத்துவ உயிர் இயற்பியல் , ப்ரிந்ஸெஸ் மார்கரெட் , ஹெலன் லூ யா , மூத்தவர் விஞ்ஞானி , மூலக்கூறு செல் , இணை ப்ரொஃபெஸர் , மருத்துவ உயிர் இயற்பியல் , புற்றுநோய் சிகிச்சை , நோயெதிர்ப்பு சிகிச்சை , டி செல் ,

Climate change may have contributed to the COVID-19 pandemic

Climate change may have contributed to the COVID-19 pandemic
Thought LeadersDr. Robert BeyerMarie Curie Research FellowPostdam Institute for Climate Impact Research
In this interview, News-Medical speaks to Dr. Robert Beyer about his latest research that discovered that climate change may have contributed to the COVID-19 pandemic.
What provoked your research into the ongoing COVID-19 pandemic?
We began the study after genetic data first indicated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19 disease, had originated in bats. We had also been aware of research demonstrating the impact that climate change can have in facilitating disease transmissions. ....

France General , United Kingdom , Marie Curie , Technische Universit , Robert Beyer , Rudmer Zwerver Shutterstock , Emily Henderson , Kateryna Kon Shutterstock , University Of Cambridge , Potsdam Institute For Climate Impact Research , Kyoto University , Climate Impact , Image Credit , Chinese Yunnan , Potsdam Institute , Climate Impact Research , Coronavirus Disease Covid 19 , Corona Virus , Infectious Diseases , Sars Cov 2 , பிரான்ஸ் ஜநரல் , ஒன்றுபட்டது கிஂக்டம் , மேரி கியூரி , ராபர்ட் பேயர் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் கேம்பிரிட்ஜ் ,