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Lewy body dementia may share similar genetic profiles with Alzheimer's disease

In a study led by National Institutes of Health (NIH) researchers, scientists found that five genes may play a critical role in determining whether a person will suffer from Lewy body dementia, a devastating disorder that riddles the brain with clumps of abnormal protein deposits called Lewy bodies. ....

United States , Bryanj Traynor , Clifton Dalgard , Sonja Scholz , Emily Henderson , American Genome Center , National Institutes Of Health , Uniformed Services University Of The Health Sciences , National Library Of Medicine , National Institute On Aging , National Institute Of Neurological Disorders , National Institutes , Nature Genetics , Study Senior Author , National Institute , Neurological Disorders , Uniformed Services University , Health Sciences , National Library , Alzheimer 39s Disease , Lewy Bodies , Medical Research , Nervous System , Neurodegenerative Diseases , Parkinson 39s Disease , ஒன்றுபட்டது மாநிலங்களில் ,

Study highlights the epigenetics of life at high altitudes

Study highlights the epigenetics of life at high altitudes
Humans inhabit an incredible range of environments across the globe, from arid deserts to frozen tundra, tropical rainforests, and some of the highest peaks on Earth. Indigenous populations that have lived in these extreme environments for thousands of years have adapted to confront the unique challenges that they present.
Approximately 2% of people worldwide live permanently at high altitudes of over 2,500 meters (1.5 miles), where oxygen is sparse, UV radiation is high, and temperatures are low. Native Andeans, Tibetans, Mongolians, and Ethiopians exhibit adaptations that improve their ability to survive such conditions. Andeans, for example, display increased chest circumference, elevated oxygen saturation, and a low hypoxic ventilatory response, enabling them to thrive at exceptionally high elevations. ....

Cerro De Pasco , United States , Ainash Childebayeva , Emily Henderson , Cayetano Heredia University , Department Of Archaeogenetics , University Of Michigan , Genome Biology , Wide Epigenetic Signatures , Adaptive Developmental Plasticity , Peruvian Quechua , Andean Altiplano , Cerro De Pasco High Altitude , Max Planck Institute , Human History , Central Asia , Dna Methylation , சிஇஆர்ஆர்ஓ டி பாஸ்கோ , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , கேயேதானோ பரம்பரை பல்கலைக்கழகம் , பல்கலைக்கழகம் ஆஃப் மிச்சிகன் , மரபணு உயிரியல் , பரந்த எபிஜெனெடிக் கையொப்பங்கள் , பெருவியன் க்வ்ய்க்ஃப்வா , சிஇஆர்ஆர்ஓ டி பாஸ்கோ உயர் உயரம் ,

Plant breeding can help increase crop productivity, reduce human malnutrition

Plant breeding can help increase crop productivity, reduce human malnutrition
Your morning cereal or oatmeal. The bread on your sandwich. The corn chips for your snack, and the cookies for dessert. Not one would be possible with the humblest of ingredients: the seed.
Seeds such as wheat, rice, and corn directly provide about 70% of the calories eaten by people every day. And they ultimately provide nearly every morsel of food, either by providing feed for livestock or by being grown into fruits and vegetables. It s no overstatement to say that without seeds, civilization would be impossible.
But seeds need our help. They are under stress from climate change, and under pressure to feed a growing population. ....

United States , Rodomiro Ortiz , Emily Henderson , Swedish University Of Agricultural Sciences , Crop Science Society Of America , Crop Science , Crop Science Society , Plant Breeding , Swedish University , Genetic Engineering , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , பயிர் அறிவியல் சமூகம் ஆஃப் அமெரிக்கா , பயிர் அறிவியல் , பயிர் அறிவியல் சமூகம் , ஆலை இனப்பெருக்க , ஸ்விட்ச் பல்கலைக்கழகம் , ஜெநெடிக் பொறியியல் , மன அழுத்தம் ,

Genetic testing technology wrongly detects the presence of very rare genetic variants

A technology that is widely used by commercial genetic testing companies is "extremely unreliable" in detecting very rare variants, meaning results suggesting individuals carry rare disease-causing genetic variants are usually wrong, according to new research published in the BMJ. ....

Caroline Wright , Ileigh Jackson , Emily Henderson , University Of Exeter Medical School , University Of Exeter , Study Senior Author , Genomic Medicine , Exeter Medical , United Kingdom Biobank , Personal Genome , United Kingdom , Breast Cancer , Medical School , Rare Disease , Type 2 Diabetes , Uk Biobank , கரோலின் ரைட் , லே ஜாக்சன் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் எக்ஸெடர் மருத்துவ பள்ளி , பல்கலைக்கழகம் ஆஃப் எக்ஸெடர் , படிப்பு மூத்தவர் நூலாசிரியர் , எக்ஸெடர் மருத்துவ , தனிப்பட்ட மரபணு , ஒன்றுபட்டது கிஂக்டம் , மார்பக புற்றுநோய் ,

Kruppel-like factor 15 controls skeletal muscle fat uptake and utilization

Kruppel-like factor 15 controls skeletal muscle fat uptake and utilization
Metabolic diseases, such as obesity and type 2 diabetes, have risen to epidemic proportions in the U.S. and occur in about 30 percent of the population. Skeletal muscle plays a prominent role in controlling the body s glucose levels, which is important for the development of metabolic diseases like diabetes.
In a recent study, published in
The Journal of Clinical Investigation, University Hospitals (UH) Cleveland Medical Center and Case Western Reserve University School of Medicine researchers have found that skeletal muscle significantly affects how the body stores and metabolizes fat.
In the study, Mukesh K. Jain, MD, senior author, Chief Academic Officer at UH, and the Ellery Sedgwick Jr. Chair & Distinguished Scientist, and his team set out to investigate the role of a gene called Kruppel-like factor 15 (KLF15) in skeletal muscle. The team utilized a mouse model with KLF15 specifically ....

Ellery Sedgwick Jr , Mukeshk Jain , Emily Henderson , Harrington Discovery Institute , University Hospitals Uh Cleveland Medical Center , Case Western Reserve University School Of Medicine , Clinical Investigation , University Hospitals , Cleveland Medical Center , Case Western Reserve University School , Chief Academic Officer , Ellery Sedgwick , Distinguished Scientist , Vice Dean , University Hospitals Affairs , Case Western Reserve , Chief Scientific Officer , Study First , Fatty Liver , Insulin Resistance , Liver Disease , Metabolic Disease , Mouse Model , Type 2 Diabetes , எல்லேரி ஸெட்ஜ்‌விக் ஜூனியர் , எமிலி ஹென்டர்சன் ,