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Evolution of the spike gene of SARS-CoV-2 for human adaptation


Evolution of the spike gene of SARS-CoV-2 for human adaptation
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected over 111 million individuals worldwide and has resulted in the COVID-19 pandemic. Many pangolin and bat-derived viruses are closely related to SARS-CoV-2, which suggests its likely zoonotic origin.
Researchers have found a 96% similarity in nucleotide sequence between bat coronavirus (RaTG13), isolated from
s in China in 2013, and SARS-CoV-2 and ~97% amino acid similarity with the Spike (S) protein. This S protein performs two essential roles, i.e., mediates receptor-binding and membrane fusion. Hence, spike protein is regarded as a key coronavirus determinant of host tropism. ....

Priyom Bose , Middle East , Non Synonymous , Image Credit , West Nile , Sars Cov 2 , Amino Acid , Corona Virus , Coronavirus Disease Covid 19 , Mers Cov , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , பிரீயோம் போஸ் , நடுத்தர கிழக்கு , படம் கடன் , மேற்கு நைல் , அமினோ அமிலம் , கொரோனா வைரஸ் , மேற்ச் கோவ் , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

Superspreader events trigger emergence of novel SARS-CoV-2 variants in USA


Superspreader events trigger emergence of novel SARS-CoV-2 variants in USA
A team of scientists from the USA and Germany has recently studied the evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a representative set of sequences from the USA collected between 2020 and 2021. The findings reveal that the viral genome has accumulated multiple mutations over time with only occasional loss of mutation. The main driving forces behind such genetic variations include widespread infection and superspreader events. The study is currently available on the
Background
Within one year of its emergence, SARS-CoV-2, the causative pathogen of coronavirus disease 2019 (COVID-19), has infected 110 million people and claimed 2.4 million lives globally. SARS-CoV-2 is a single-stranded, positive-sense, enveloped virus of the ....

United States , Thomas Stockhausen Shutterstock , Sanchari Sinha Dutta , Thomas Stockhausen Shutterstock Sars Co , Founder Events , Collection Date , Thomas Stockhausen , Coronavirus Disease Covid 19 , Sars Cov 2 , Amino Acid , Corona Virus , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஒன்றுபட்டது மாநிலங்களில் , சஞ்சரி சீன்ஹா தத்தா , நிறுவனர் நிகழ்வுகள் , சேகரிப்பு தேதி , தாமஸ் ஸ்டாக்‌ஹாஸந் , அமினோ அமிலம் , கொரோனா வைரஸ் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

Neanderthal gene can confer protection against severe COVID-19, finds study


Neanderthal gene can confer protection against severe COVID-19, finds study
Some of the genes in the human genome appear to confer a protective effect against severe coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A new paper published online in the journal
PNAS describes genes involved in innate immunity that have undergone variations between different human subgroups.
Infectious disease and genetic changes
Infectious diseases vary in prevalence with environmental conditions, which vary dramatically in different parts of the world. These act as selective factors on gene variants, such as the toll-like receptor gene variants that reduce the susceptibility to some bacterial infections and allergies. ....

United States , Liji Thomas , Host Genetics Initiative , Image Credit , South Asia , Critical Care , African Yoruba , Genetics Initiative , Native American , West Nile , Coronavirus Disease Covid 19 , Sars Cov 2 , Chromosome 12 , Chromosome 3 , Corona Virus , Infectious Diseases , Intensive Care , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஒன்றுபட்டது மாநிலங்களில் , தொகுப்பாளர் ஜெநெடிக்ஸ் முயற்சி , படம் கடன் , தெற்கு ஆசியா , முக்கியமான பராமரிப்பு , ஜெநெடிக்ஸ் முயற்சி , பூர்வீகம் அமெரிக்கன் ,

Some SARS-CoV-2 variants evade mRNA vaccine-induced humoral immune, says study