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Genomic surveillance can help identify how SARS-CoV-2 spreads in care homes

Genomic surveillance can help identify how SARS-CoV-2 spreads in care homes
Care homes are at high risk of experiencing outbreaks of COVID-19, the disease caused by SARS-CoV-2. Older people and those affected by heart disease, respiratory disease and type 2 diabetes - all of which increase with age - are at greatest risk of severe disease and even death, making the care home population especially vulnerable.
Care homes are known to be high-risk settings for infectious diseases, owing to a combination of the underlying vulnerability of residents who are often frail and elderly, the shared living environment with multiple communal spaces, and the high number of contacts between residents, staff and visitors in an enclosed space. ....

United Kingdom , Gerry Tonkin Hill , Emily Henderson , University Of Cambridge , Public Health England , Genomics United Kingdom Consortium , Laboratory In Cambridge , Cambridge University Hospitals , Wellcome Sanger Institute , Honorary Consultant , Honorary Senior Visiting Fellow , William Hamilton , Wellcome Sanger , Health Care , Heart Disease , Infection Control , Infectious Diseases , Respiratory Disease , Sars Cov 2 , Type 2 Diabetes , ஒன்றுபட்டது கிஂக்டம் , ஜெர்ரி டான்கின் மலை , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் கேம்பிரிட்ஜ் , பொது ஆரோக்கியம் இங்கிலாந்து , மரபியல் ஒன்றுபட்டது கிஂக்டம் கூட்டமைப்பு ,

Researchers identify the trigger of key cellular change in amyotrophic lateral sclerosis

Researchers identify the trigger of key cellular change in amyotrophic lateral sclerosis
Scientists at the Francis Crick Institute and UCL have identified the trigger of a key cellular change in amyotrophic lateral sclerosis (ALS), a type of motor neurons disease. The findings could help develop new treatments for many neurological diseases with the same change, including Parkinson s and Alzheimer s.
When the nervous system is injured, diseased or infected, star-shaped cells, called astrocytes, undergo reactive changes in their behavior. Whilst some of these reactive astrocytes become protective, others become harmful and damage surrounding motor neurons.
Reactive astrocytes are observed in various neurodegenerative diseases including ALS, but there is a lack of understanding about what causes astrocytes to undergo this change. ....

Oliver Ziff , Rickie Patani , Emily Henderson , National Hospital For Neurology , Queen Square Institute Of Neurology , Group Leader , Nucleic Acids Research , Francis Crick Institute , Senior Study Author , Queen Square Institute , Consultant Neurologist , National Hospital , Square Institute , Motor Neurone Disease , Amyotrophic Lateral Sclerosis , Genetic Information , Motor Neurons , Nervous System , Neurodegenerative Diseases , Stem Cells , ஆலிவர் ஸிஃப் , ரிக்கி படானி , எமிலி ஹென்டர்சன் , தேசிய மருத்துவமனை க்கு நரம்பியல் , ராணி சதுரம் நிறுவனம் ஆஃப் நரம்பியல் , குழு தலைவர் ,

Evolutionary forces account for gender imbalance in the occurrence of autism, other health conditions

Evolutionary forces drive a glaring gender imbalance in the occurrence of many health conditions, including autism, a team of genetics researchers has concluded. ....

Rama Singh , Karun Singh , Emily Henderson , University Of Toronto , Shiva Singh , Associate Professor , Cervical Cancer , Mental Health , Ovarian Cancer , ராமா சிங் , கருண் சிங் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் டொராண்டோ , சிவா சிங் , இணை ப்ரொஃபெஸர் , மன இறுக்கம் , சிஇஆர்விஐசிஏஎல் புற்றுநோய் , மன ஆரோக்கியம் , ஓவாயரியந் புற்றுநோய் ,

New Clock Can Measure Biological Age Precisely

New Clock Can Measure Biological Age Precisely
by Anjanee Sharma on
March 4, 2021 at 3:43 PM
The BiT age (binarized transcriptomic aging clock) was developed by David Meyer and Professor Dr. Björn Schumacher.
Biological age differs substantially for everyone. Aging clocks like Horvath s epigenetic clock have been based on the pattern of methylations until now. These patterns are small chemical groups that attach to DNA and change with age.
The BiT age clock takes the set of genes read from DNA to make proteins for the cell into account.
Earlier the transcriptome was considered too complex to indicate age as sometimes genes transcribe a large amount of mRNA and sometimes less. So it was impossible to develop precise aging clocks based on gene activity. ....

David Meyer , Biological Age , Epigenetic Clock , டேவிட் மேயர் , உயிரியல் வாழ்நாள் , எபிஜெனெடிக் கடிகாரம் ,

Researchers develop a genetic patch to prevent hereditary deafness

They can hear well up to about forty years old, but then suddenly deafness strikes people with DFNA9. The cells of the inner ear can no longer reverse the damage caused by a genetic defect in their DNA. ....

Van Wijk , Erwin Van Wijk , Emily Henderson , Southern Netherlands , Molecular Therapy , வேன் விஜக் , அர்‌விந் வேன் விஜக் , எமிலி ஹென்டர்சன் , தெற்கு நெதர்லாந்து , மூலக்கூறு சிகிச்சை ,