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Researchers develop saliva testing method for SARS-CoV-2 using robotic RNA extraction

Researchers develop saliva testing method for SARS-CoV-2 using robotic RNA extraction
Researchers have developed an automated method of RNA extraction from saliva samples to allow faster processing times and high test sensitivity. Saliva testing could be used as an alternative to swab testing for coronavirus disease 2019 (COVID-19) surveillance.
Overview of nucleic acid extraction from saliva specimens a , Overview of Innovative Genomics Institute’s (IGI’s) specimen processing pipeline for both swab and saliva samples. OP = oropharyngeal. OP-MT = oropharyngeal-mid turbinate. b , Cultured SARS-CoV-2 (1.58x10 6 TCID50/ml) was mixed 1:1 with OMNIgene solution present in OM-505 collection tubes to test incubation conditions that inactivate viral replication. Samples were either held at room temperature (RT) or incubated at 65°C for the indicated length of time before being applied to Vero-E6 cells. Cytopathic effect (CPE) was quantified at 3 and 7 days post treatment (d ....

United States , Lakshmi Supriya , Genotek Omnigene , University Of California , Overview Of Innovative Genomics Institute , Washington Hospital Healthcare System Clinical Laboratory , Phd Jan , Innovative Genomics Institute , Coronavirus Disease Covid 19 , Rna Extraction , Sars Cov 2 , Corona Virus , Nucleic Acid , Ribonucleic Acid , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஒன்றுபட்டது மாநிலங்களில் , லட்சுமி சுப்ரியா , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , ஓவர்‌வ்யூ ஆஃப் புதுமையானது மரபியல் நிறுவனம் , வாஷிங்டன் மருத்துவமனை சுகாதாரம் அமைப்பு மருத்துவ ஆய்வகம் , ஃப்ட் ஜான் , புதுமையானது மரபியல் நிறுவனம் , ர்ந பிரித்தெடுத்தல் , கொரோனா வைரஸ் , கடுமையானது எடுப்போசை சுவாச ,

Synthetic lung organoids provide high-throughput platform to identify new cellular targets of SARS-CoV-2

An interesting new study published on the bioRxiv preprint server describes a new platform that allows a high-throughput workflow to generate matched human lung buds in the tens of thousands. This allows researchers to study SARS-CoV-2 infection and therapeutics in lung tissue that mirrors the key aspects of human lung development. ....

Liji Thomas , Coronavirus Disease Covid 19 , Lung Organoids , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Corona Virus , In Vitro , Progenitor Cells , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Stem Cells , கொரோனா வைரஸ் , இல் விட்ரோ , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , தண்டு செல்கள் ,

New Study: No Genes to Predict "Mental illness"

A new study of about 50,000 people failed to find any genes that influenced “mental illness.” ....

Thivia Balakrishna , David Curtis , University College London , Genetics Institute , University College , United Kingdom Biobank , Affective Disorders , Genetic Risk For Mental Illness , Genetic Testing , டேவிட் கர்டிஸ் , பல்கலைக்கழகம் கல்லூரி லண்டன் , ஜெநெடிக்ஸ் நிறுவனம் , பல்கலைக்கழகம் கல்லூரி , உவ்ர்ச்சி சார்ந்த கோளாறுகள் , ஜெநெடிக் ஆபத்து க்கு மன உடல் நலமின்மை , ஜெநெடிக் சோதனை ,

Study shows P681H mutation is becoming globally prevalent among SARS-CoV-2 sequences

Study shows P681H mutation is becoming globally prevalent among SARS-CoV-2 sequences
In a recent
bioRxiv preprint study, researchers from the University of Hawaii showed that the S gene of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuously mutating according to the sequence and phylogenetic analysis. At the same time, a unique strain with an emerging mutation in an altered spike glycoprotein may be present in Hawaii.
Over the past year, there was a notable evolution of SARS-CoV-2 around the globe, which will continue to pose a serious threat. As of January 2021, four novel viral variants have been reported from the United Kingdom (VOC 202012/01/B.1.1.7), South Africa (501Y.V2), Nigeria (B.1.207), and Denmark (Mink Cluster V). ....

United Kingdom , South Africa , United States , Davidp Maison , University Of Hawaii , Genetic Characteristics , Hawaii Reveals , Image Credit , Medicine Biocontainment Facility , Maximum Likelihood , Gene Region , Study Along , Annotated Primers , Cysteine Residues , Receptor Binding Domain Figure , Insightful Science , New York , Native Hawaiians , Pacific Islanders , Sars Cov 2 , Corona Virus , Coronavirus Disease Covid 19 , Sanger Sequencing , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஒன்றுபட்டது கிஂக்டம் ,

Research opens up hope-filled possibilities for new autism therapies

Research opens up hope-filled possibilities for new autism therapies
Recent years have provided substantial research displaying the effect of genetic mutations on the development of autism and other neurodevelopmental disorders. Based on those studies, researchers have focused attention on the commonalities behind those mutations and how they impact on the functioning of the brain.
A study conducted by Professor Sagiv Shifman from the Life Sciences Institute at the Hebrew University of Jerusalem and the Center for Autism Research has found that genes associated with autism tend to be involved in the regulation of other genes and to operate preferentially in three areas of the brain; the cortex, the striatum, and the cerebellum. ....

Israel General , Hebrew University , Sagiv Shifman , Yosef Yarom , Emily Henderson , Autism Research , Nature Communications , Brain Sciences At Hebrew University , Hebrew University Of Jerusalem , Life Sciences Institute , Edmond Lily Safra Center , Professor Sagiv Shifman , Professor Shifman , Professor Yosef Yarom , Lily Safra Center , Brain Sciences , Professor Yarom , இஸ்ரேல் ஜநரல் , ஹீப்ரு பல்கலைக்கழகம் , எமிலி ஹென்டர்சன் , மன இறுக்கம் ஆராய்ச்சி , இயற்கை தகவல்தொடர்புகள் , மூளை அறிவியல் இல் ஹீப்ரு பல்கலைக்கழகம் , ஹீப்ரு பல்கலைக்கழகம் ஆஃப் ஏருசலேம் , வாழ்க்கை அறிவியல் நிறுவனம் , எட்மண்ட் லில்லி சஃப்ரா மையம் ,