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Study could lay foundation for developing drugs that treat or prevent cocaine addiction, and provides contextual framework for future research.
Credit: Clemson University New research from the Clemson University Center for Human Genetics has identified specific cell clusters in the brain of the common fruit fly affected by acute cocaine exposure, potentially laying the groundwork for the development of drugs to treat or prevent addiction in humans. While cocaine's neurological effects are well known, the underlying genetic sensitivity to the drug's effects is not. In human populations, susceptibility to the effects of cocaine varies due to both environmental and genetic factors, making it challenging to study. Approximately 70 percen...
E-Mail IMAGE: Robert Anholt and Trudy Mackay in a lab holding a test tube containing Drosophila melanogaster, the common fruit fly. view more Credit: Clemson University College of Science Researchers Trudy Mackay and Robert Anholt of the Clemson University Center for Human Genetics have joined forces with an international consortium intended to drive research that will shape regulation and policy on chemical safety without the use of animal testing. Mackay, an internationally renowned scientist and director of the Center for Human Genetics (CHG), will team with Anholt to explore ...
w 1118. ( B) Heatmap of the expression of TSC genes averaged across 2 days of observation. The presence of the characteristic circadian patterns in the tissue is indicated with black rectangles around the heatmaps. The number at the left designates the number of detected TSC genes. ( C and D) Heatmap of cycling in two (C) and three tissues (D) gene expression averaged across 2 days of observation. Black rectangles indicate tissues in which genes were found to be cycling. For (B) to (D), lighter areas or the heatmaps correspond to lower expression levels. The time is indicated at the bottom o...