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Study uncovers genetic similarities between PTSD and other mental health disorders

Study uncovers genetic similarities between PTSD and other mental health disorders
Attempts to identify the genetic causes of neuropsychiatric diseases such as post-traumatic stress disorder (PTSD) through large-scale genome-wide analyses have yielded thousands of potential links. The challenge is further complicated by the wide range of symptoms exhibited by those who have PTSD. For instance, does extreme arousal, anger, or irritation experienced by some have the same genetic basis as the tendency to re-experience traumatic events, another symptom of the disorder?
A new study led by researchers at Yale and the University of California-San Diego (UCSD) provides answers to some of these questions and uncovers intriguing genetic similarities between PTSD and other mental health disorders such as anxiety, bipolar disorder, and schizophrenia. ....

United States , San Diego , Murray Stein , Joel Gelernter , Emily Henderson , Yale University , University Of California , Public Health , Million Veteran Program , Us Veterans Administration , Foundations Fund Professor Of Psychiatry , California San Diego , Foundations Fund Professor , Distinguished Professor , Bipolar Disorder , Post Traumatic Stress Disorder , ஒன்றுபட்டது மாநிலங்களில் , சான் டியாகோ , முர்ரே ஸ்டீன் , எமிலி ஹென்டர்சன் , யேல் பல்கலைக்கழகம் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , பொது ஆரோக்கியம் , மில்லியன் மூத்த ப்ரோக்ர்யாம் , அடித்தளங்கள் நிதி ப்ரொஃபெஸர் ஆஃப் மனநல மருத்துவம் , கலிஃபோர்னியா சான் டியாகோ ,

New method shows promise in identifying disease-fighting drug targets

Professor Ron Quinn AM, Principal Research Leader at the Griffith Institute for Drug Discovery.
A new method of identifying molecular targets to fight disease could help accelerate future drug development new Griffith University research published in Scientific Reports has found.
“Even in this molecular era of drug discovery, there remain new investigational drugs whose molecular targets are unclear, restricting their optimisation and broad use in disease,” Professor Quinn said.
Protein 4J57 – “Plasmodium falciparum thioredoxin reductase-thioredoxin complex”
“A key step in the discovery of new pharmaceutical drugs and developing them to useful treatments for patients is, therefore, the identification of the molecular target while, at the same time, ensuring the drug does not interact with other gene products that would cause side effects.” ....

Miaomiao Liu , Griffith University , Principal Research Leader , Griffith Institute For Drug Discovery , Professor Ron Quinn , Griffith Institute , Scientific Reports , Drug Discovery , Drug Development , கிரிஃபித் பல்கலைக்கழகம் , ப்ரிந்ஸிபல் ஆராய்ச்சி தலைவர் , கிரிஃபித் நிறுவனம் க்கு மருந்து கண்டுபிடிப்பு , ப்ரொஃபெஸர் ரோன் க்வின் , கிரிஃபித் நிறுவனம் , அறிவியல் அறிக்கைகள் , மருந்து கண்டுபிடிப்பு , மருந்து வளர்ச்சி ,

Plants depend on LEAFY protein that enables cells to change their fate

Plants depend on LEAFY protein that enables cells to change their fate
Cells don t express all the genes they contain all the time. The portion of our genome that encodes eye color, for example, doesn t need to be turned on in liver cells. In plants, genes encoding the structure of a flower can be turned off in cells that will form a leaf.
These unneeded genes are kept from becoming active by being stowed in dense chromatin, a tightly packed bundle of genetic material laced with proteins.
In a new study in the journal
Nature Communications, biologists from the University of Pennsylvania identified a protein that enables plant cells to reach these otherwise inaccessible genes in order to switch between different identities. ....

Doris Wagner , Kenneth Zaret , Emily Henderson , Nature Communications , School Of Arts Sciences , University Of Pennsylvania , Perelman School Of Medicine , Study Senior Author , Perelman School , Transcription Factors , டோரிஸ் வாக்னர் , எமிலி ஹென்டர்சன் , இயற்கை தகவல்தொடர்புகள் , பள்ளி ஆஃப் கலைகள் அறிவியல் , பல்கலைக்கழகம் ஆஃப் பென்சில்வேனியா , பெரல்மேன் பள்ளி ஆஃப் மருந்து , படிப்பு மூத்தவர் நூலாசிரியர் , பெரல்மேன் பள்ளி , படியெடுத்தல் காரணிகள் ,

Viral ExoN regulates the rate of recombination in SARS-CoV-2

Viral ExoN regulates the rate of recombination in SARS-CoV-2
Researchers at Vanderbilt University Medical Center (VUMC) and the University of Texas Medical Branch (UTMB) at Galveston have discovered what may be the Achilles heel of the coronavirus, a finding that may help close the door on COVID-19 and possibly head off future pandemics.
The coronavirus is an RNA virus that has, in its enzymatic toolkit, a proofreading exoribonuclease, called nsp14-ExoN, which can correct errors in the RNA sequence that occur during replication, when copies of the virus are generated.
Using cutting-edge technologies and novel bioinformatics approaches, the researchers discovered that this ExoN also regulates the rate of recombination, the ability of the coronavirus to shuffle parts of its genome and even pull in genetic material from other viral strains while it replicates in order to gain evolutionary advantage. ....

Mark Denison , James Chappell , Andrea Pruijssers , Maria Agostini , Jennifer Gribble , Emily Henderson , Xiaotao Lu , Edward Claiborne Stahlman , Laura Stevens , Andrew Routh , Vanderbilt University Medical Center , Researchers At Vanderbilt University Medical Center , Study Co , Vanderbilt University School Of Medicine , University Of Texas Medical Branch , Division Of Pediatric Infectious Diseases , Texas Medical Branch , Middle Eastern , Molecular Biology , Pediatric Infectious Diseases , Jordan Anderson Daniels , Edward Claiborne Stahlman Chair , Pediatric Physiology , Cell Metabolism , Vanderbilt University School , Study Co Corresponding Author ,

Progeria study finds base-editing therapy lengthens lifespan in mice

Luke Koblan sat at his desk, staring at some data. Excited but baffled, the grad student thought, there’s no way those numbers could be right. He shared the results with his boss, Professor David Liu, and today, that data has spurred a team of scientists from the Broad Institute of MIT and Harvard (including Koblan and Liu), the National Institutes of Health, and Vanderbilt University Medical Center to achieve an almost unbelievable leap for the CRISPR gene-editing tool known as base editing, moving the technology a critical step closer to being a treatment for progeria, a deadly premature aging disease. ....

Leslie Gordon , Jonathan Brown , Charles Lin , Michael Erdos , Brown University , Dana Farber Cancer Institute , Progeria Research Foundation , Cardiovascular Medicine , Vanderbilt University Medical Center , Base Editing , Base Editors , Broad Institute , Caitlin Mcdermott Murphy , Chemistry And Chemical Biology , David Liu , Francis Collins , Gene Editing , Genetic Disease , Genetic Engineering , Howard Hughes Medical Institute , National Institutes Of Health , லெஸ்லி கோர்டந் , ஜொனாதன் பழுப்பு , சார்லஸ் லின் , மைக்கேல் ஏர்தோஸ் , பழுப்பு பல்கலைக்கழகம் ,