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NICER: A safer alternative to CRISPR/Cas9 for gene editing

The gene editing technique CRISPR/Cas9 has allowed researchers to make precise and impactful changes to an organism's DNA to fix mutations that cause genetic disease. ....

Shinichiro Nakada , Lily Ramsey , Akiko Tomita , Osaka University , Nature Communications , Osaka University Led , Genome Editing , Homologous Recombination , Somatic Cells ,

Genomic sequencing as a first-tier screening test for newborns

1. In this prospective cohort study, 1 out of 500 newborns were diagnosed with a medical condition that was detected via genetic sequencing but was missed by more commonly used biochemical screening tests. Evidence rating level: 1 (Excellent) Newborn screening (NBS) is routinely performed across the world using biochemical testing methods. The effectiveness of genetic ....

Newborn Screening , Public Health ,

Genetic test: Genetic test that saved infant's life offers hope for millions more, says research

A recent study published in the Journal of the American Medical Association found that "whole genome" tests are twice as effective as narrower tests in identifying genetic abnormalities that can cause disease in infants. ....

United States , Sleeping Beauty , Rhode Island , Mara Aspinall , Philip Brooks , Mike Schulte , Lindsay Schulte , Amanda Denaro , Brynn Schulte , Cristina Tarango , Jon Davis , Jill Maron , Paul Kurszka , Journal Of The American Medical Association , Cincinnati Children Hospital Medical Center , Arizona State University , National Institutes Of Health , Us National Human Genome Research Institute , American Medical , Might Also Like , Human Genome Research Institute , Tufts Children , Cincinnati Children , Hospital Medical Center , Infants Hospital , Cash Denaro ,

BBCNEWS The Context June 4, 2024 19:55:00

It s no evidence it s associated with more severe disease and the people that get it, but what sparked the interest of scientists is that it does have a very extensive repertoire of genetic mutations in the virus, more than 30, many of the mapping out the parts of the virus that affect how the virus is seen by our immune system which means it might have potential to dodge around our pre existing immunity. on the other hand some scientists have pointed out the changes also affect parts of the genome that we know make the virus less able to spread and cause disease, so it may be that it s a seesaw effect and there are some changes that make it worse, some changes that make it worse, some that compensate and therefore overall it ll probablyjust fizzle out. overall it ll probably ust fizzle out. ~ . overall it ll probably ust fizzle out. 2 ., , overall it ll probably ust fizzle out.2 2, , . out. we are hoping it s the latter. we are out out. we are hoping it s the latter. we are out ....

Immune System , Seesaw Effect , People Go Out , Ust Fizzle Out 2 , Ust Fizzle Out , Anti Virals , South East Quadrant ,

We know almost nothing about thousands of proteins in the human body

Scientists have created an "unknome" of proteins encoded by human genes, whose existence is known but whose functions are mostly not ....

United Kingdom , Sean Munro , Laboratory Of Molecular Biology In Cambridge , Molecular Biology , Gene Ontology ,