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Cell Host & Microbe, the findings generate invaluable insight into how gut microbes break down processed foods and lower the risk of health conditions often associated with those foods, such as obesity and diabetes. Microbes mitigate the effects of processed foods When food is processed or cooked at high temperatures, a chemical reaction between amino acids and sugars leads to the formation of chemicals known as Maillard Reaction Products (MRPs). Depending on how the food was processed, MRPs can either be beneficial or toxic. With processed foods, it is often the case that the MRPs are tox...

Scientists publish new analysis of most diverse genetic data set Researchers at the University of Maryland School of Medicine (UMSOM) and their colleagues published a new analysis today in the journal Nature from genetic sequencing data of more than 53,000 individuals, primarily from minority populations. The early analysis, part of a large-scale program funded by the National Heart, Lung, and Blood Institute, examines one of the largest and most diverse data sets of high-quality whole genome sequencing, which makes up a person's DNA. It provides new genetic insights into heart, lung, blood ...

Integrative Approaches to Identifying Function and Significance of Adiposity Susceptibility Genes In 2019, ~100 million Americans were obese, fueling increases in obesity-related morbidity, mortality, and health care costs, largely from cardiometabolic diseases (CMD). GWAS have demonstrated the fundamental role of genetic susceptibility in obesity risk, including the >1000 loci identified to date. Each GWAS-identified locus potentially provides novel biologic insight; yet the identification of the functional variants, genes, and underlying pathways at these loci has limited translation for pr...

Eric Lander Illustration: Alex Hogan/STAT; Photo: AP WASHINGTON — Joe Biden’s presence at meetings of the Obama administration’s scientific advisory council sometimes tested his staff’s patience. It wasn’t that the vice president was unwelcome, of course. It was that Biden’s tendency to linger long after the meetings ended invariably caused scheduling hiccups. From his seat across the table from Eric Lander, then the council’s co-chair, Biden would pepper the group with questions about cancer research, climate change, and everything in between. On several occas...

To embed, copy and paste the code into your website or blog: Our “Innovation Conversations” series continues with our guest Dr. Claire Fraser, President of the American Association for the Advancement of Science (AAAS) and Director of the Institute for Genome Sciences at the University of Maryland School of Medicine. Sterne Kessler Director Trey Powers discussed several topics with Dr. Fraser including: her professional achievements and career challenges; bioprospecting in Yellowstone National Park; the importance of genome sequencing; perspectives on the U.S. patent system; and hopes for...