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Large-scale genome sequencing shows how SARS-CoV-2 mutated

A new study published on the preprint server bioRxiv describes the results of genomic sequencing of the virus, which may help trace the routes of transmission of the virus from person to person, and from country to country. ....

United States , United Kingdom , Liji Thomas , Global Initiative For Sharing All Influenza Data , Middle East , Global Initiative , Sharing All Influenza Data , Diamond Princess , Grand Princess , Image Credit , Western Europe , Washington State , Spring Festival , New York City , Sars Cov 2 , Corona Virus , Coronavirus Disease Covid 19 , Genomic Sequencing , Mers Cov , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , நடுத்தர கிழக்கு , உலகளாவிய முயற்சி , வைரம் ப்ரிந்ஸெஸ் ,

Modeling study sheds light on SARS-CoV-2 genome packaging

Modeling study sheds light on SARS-CoV-2 genome packaging
Researchers at the University of North Carolina at Chapel Hill have conducted a study exploring how the spatial patterning of certain genomic RNA regions in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) promotes compaction, packaging, and cyclization of the viral genome.
The novel SARS-CoV-2 virus is the agent responsible for the coronavirus disease 2019 (COVID-19) pandemic that continues to sweep the globe posing an unprecedented threat to global health and the worldwide economy.
A significant challenge for viruses such as SARS-CoV-2 is the specific and efficient packaging of a large genome into a relatively small capsid while excluding viral subgenomic fragments and cellular nucleic acids. ....

Amy Gladfelter , Sally Robertson , University Of North Carolina At Chapel Hill , North Carolina , Chapel Hill , Image Credit , Sars Cov 2 , Corona Virus , Coronavirus Disease Covid 19 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , சாலி ராபர்ட்சன் , பல்கலைக்கழகம் ஆஃப் வடக்கு கரோலினா இல் தேவாலயம் மலை , வடக்கு கரோலினா , தேவாலயம் மலை , படம் கடன் , கொரோனா வைரஸ் , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

Study shows P681H mutation is becoming globally prevalent among SARS-CoV-2 sequences

Study shows P681H mutation is becoming globally prevalent among SARS-CoV-2 sequences
In a recent
bioRxiv preprint study, researchers from the University of Hawaii showed that the S gene of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuously mutating according to the sequence and phylogenetic analysis. At the same time, a unique strain with an emerging mutation in an altered spike glycoprotein may be present in Hawaii.
Over the past year, there was a notable evolution of SARS-CoV-2 around the globe, which will continue to pose a serious threat. As of January 2021, four novel viral variants have been reported from the United Kingdom (VOC 202012/01/B.1.1.7), South Africa (501Y.V2), Nigeria (B.1.207), and Denmark (Mink Cluster V). ....

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Researchers provide comprehensive molecular characterization of head and neck cancers

Researchers provide comprehensive molecular characterization of head and neck cancers
In what is believed to be the most comprehensive molecular characterization to date of the most common type of head and neck cancer, researchers from the Johns Hopkins departments of pathology and oncology, the Johns Hopkins Kimmel Cancer Center, the Johns Hopkins University School of Medicine, and 18 other centers around the U.S. and Poland have clarified the contribution of key cancer-associated genes, proteins and signaling pathways in these cancers, while proposing possible new treatment avenues.
Their deep-dive investigation of HPV-negative head and neck squamous cell carcinomas (HNSCCs), described in the Jan. 7 issue of the journal ....

Hui Zhang , Johns Hopkins , Daniel Chan , Emily Henderson , Johns Hopkins Kimmel Cancer Center , Drug Administration , Johns Hopkins University School Of Medicine , Johns Hopkins University School , Cancer Cell , Principal Investigator , Biomarker Discovery , Mass Spectrometry Core , National Cancer Institute , Clinical Proteomic Tumor Analysis Consortium , Cancer Treatment , Head And Neck Cancer , Monoclonal Antibody , Vocal Cords , ஹுய் ஜாங் , ஜான்ஸ் ஹாப்கின்ஸ் , டேனியல் சான் , எமிலி ஹென்டர்சன் , ஜான்ஸ் ஹாப்கின்ஸ் கீம்மேல் புற்றுநோய் மையம் , ஜான்ஸ் ஹாப்கின்ஸ் பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்து , ஜான்ஸ் ஹாப்கின்ஸ் பல்கலைக்கழகம் பள்ளி , புற்றுநோய் செல் ,

Researchers identify natural products with potential to disrupt viral spread

Researchers identify natural products with potential to disrupt viral spread
Researchers at Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of California San Diego have broken down the genomic and life history traits of three classes of viruses that have caused endemic and global pandemics in the past and identify natural products - compounds produced in nature - with the potential to disrupt their spread.
In a review appearing in the
Journal of Natural Products, marine chemists Mitchell Christy, Yoshinori Uekusa, and William Gerwick, and immunologist Lena Gerwick describe the basic biology of three families of RNA viruses and how they infect human cells. These viruses use RNA instead of DNA to store their genetic information, a trait that helps them to evolve quickly. The team then describes the natural products that have been shown to have capabilities to inhibit them, highlighting possible treatment st ....

Mitchell Christy , Lena Gerwick , Yoshinori Uekusa , William Gerwick , Emily Henderson , University Of California San Diego , Researchers At Scripps Institution Of Oceanography , Skaggs School Of Pharmacy , National Institutes Of Health , Scripps Oceanography Center , Scripps Institution , Skaggs School , Pharmaceutical Sciences , California San Diego , Natural Products , First Author , Marine Chemists , California San , Scripps Oceanography , Marine Biotechnology , National Institutes , Diego Chancellor , West Nile , Corona Virus , Mers Cov , மிட்செல் கிறிஸ்டி ,